In vitro method for the diagnosis of neurodegenerative diseases
AssigneeB.R.A.H.M.S GmbH
InventorsAndreas Bergmann, Andrea Ernst, Harald Hampel
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Abstract
An in vitro method for the detection, determination of severity and monitoring and prognosis of neurodegenerative diseases is disclosed. The presence and/or concentration of the physiologically inactive proadrenomedullin (proADM) partial peptide, in particular, the midregional proADM partial peptide, is determined in a biological fluid of a patient who is suffering from a neurodegenerative disease or is suspected of having such a disease. Conclusions about the presence, course, severity or success of a treatment of the neurodegenerative disease are drawn on the basis of the presence and/or concentration of the specific partial peptide in the biological sample.
Claims12
An in vitro method for the detection, for the determination of severity and for the monitoring and prognosis of neurodegenerative diseases, said method comprising determining the concentration of a physiologically inactive proadrenomedullin (proADM) partial peptide in a biological fluid of a patient who is suffering from a neurodegenerative disease or is suspected of suffering from such a disease, wherein a concentration of said proADM partial peptide that is elevated as compared to the concentration in healthy individuals is indicative of neurodegenerative disease in said patient.
Dependencies are inferred from the claim text.