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US 7,547,474 B2Granted
Lubricious coatings for pharmaceutical applications
AssigneeMed-eez, Inc.
InventorLincoln Eramo
Life of this patent
Estimating the term…
Abstract
The invention provides pills and tablets having lubricious coating deposited over the outer surface of the pills and the tablets.
Claims47
A pharmaceutical article, comprising:
- (a) a substrate comprised of a therapeutically active agent;
- and
- (b) a lubricious coating deposited over the substrate,
- wherein the article is adapted for swallowing by a mammalian subject, and wherein the coating is formed of an interpenetrating polymer network comprising a hydrophilic polymer entrapped on the surface of the substrate, and a cross-linked polymer,
- wherein the lubriciousness of the coating is between 2 and 10 times better than the lubriciousness of a standard pill coating, with the further proviso that after the subject has swallowed the article, the article is metabolized by the body of the subject, thereby bringing about a therapeutic benefit to the mammalian subject.
2 more elements
A pharmaceutical article, comprising:
- (a) a substrate comprised of a therapeutically active agent;
- and
- (b) a lubricious coating deposited over the substrate,
- wherein the article is selected from the group consisting of a pill and a tablet, and wherein the coating is formed of an interpenetrating polymer network comprising a hydrophilic polymer and a cross-linked polymer,
- wherein the lubriciousness of the coating is between 2 and 10 times better than the lubriciousness of a standard pill coating, with the further proviso that after the subject has swallowed the article, the article is metabolized by the body of the subject, thereby bringing about a therapeutic benefit to the mammalian subject.
2 more elements
A pharmaceutical article, comprising:
- (a) a substrate comprised of a therapeutically active agent;
- and
- (b) a lubricious coating deposited over the substrate,
- wherein the article is adapted for swallowing by a mammalian subject, and wherein the coating is formed of a comprising a hydrophilic polymer and a cross-linked polymer that is formed by polymerization of a monomer selected from the group consisting of acrylate, methacrylate, epoxy-acrylate, and isocyanates, or a combination thereof,
- with the further proviso that the acrylate is selected from the group consisting of monomers having at least two acrylate groups and the methacrylate is selected from the group consisting of monomers having at least two methacrylate groups,
- wherein the lubriciousness of the coating is between 2 and 10 times better than the lubriciousness of a standard pill coating, with the further proviso that after the subject has swallowed the article, the article is metabolized by the body of the subject, thereby bringing about a therapeutic benefit to the mammalian subject.
3 more elements
Dependencies are inferred from the claim text.