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US 7,547,452 B2Granted
Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
AssigneesAlkermes, Inc., Janssen Pharmaceutica NV
InventorsThomas J. Atkins, Michael E. Rickey, Jean Mesens
Life of this patent
Estimating the term…
Abstract
Sustained-release microparticle composition. The microparticle composition can be formulated to provide extended release over a period of from about 7 days to about 200 days. The microparticles may be formulated with a biodegradable and biocompatible polymer, and an active agent, such as risperidone, 9-hydroxy-risperidone, and pharmaceutically acceptable acid addition salts of the foregoing.
Claims5
A pharmaceutical product, comprising:
- microparticles comprising risperidone dispersed within a solid polymeric matrix of polylactide-co-glycolide having a molar ratio of lactide to glycolide in the range of from about 75:25 to about 50:50, wherein the amount of risperidone dispersed within the solid polymeric matrix is from about 35 to 40 weight %;
- and
- an injection vehicle, wherein the microparticles are suspended in the injection vehicle prior to administration by injection to provide a duration of action for the treatment of psychotic disorders of from about 7 days to about 200 days.
Dependencies are inferred from the claim text.