PAI-2 conjugates for the treatment and imaging of cancer
AssigneesPAI-2 Pty Limited, University of Wollongong, Medical Scitec Australia Pty Ltd.
InventorsMarie Ranson, Barry John Allen, Clive Leighton Bunn
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Abstract
A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises PAI-2 or a functional derivative, homologue, analogue, chemical equivalent or mimetic thereof, which PAI-2 is bound, linked, or otherwise associated with a toxin or label.
Claims17
A PAI-2 conjugate molecule that is internalized by a cell that expresses a uPA/uPAR complex, said molecule comprising a component (i) that is PAI-2 and, bound or linked via a chelator thereto, a component (ii) that is a radioisotope, wherein component (i) binds to uPA.
A pharmaceutical composition comprising one or more pharmaceutically acceptable carriers and/or diluents and a PAI-2 conjugate molecule that is internalized by a cell that expresses a uPA/uPAR complex, wherein said PAI-2 conjugate molecule comprises a component (i) that is PAI-2 and, bound or linked via a chelator thereto, a component (ii) that is a radioisotope, wherein component (i) binds to uPA.
Dependencies are inferred from the claim text.