Method of treating fibrosis
AssigneeZymoGenetics, Inc.
InventorDebra G. Gilbertson
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Abstract
Materials and methods for treating fibrosis in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf3 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Zvegf3 antagonists include anti-zvegf3 antibodies, mitogenically inactive receptor-binding zvegf3 variant polypeptides, and inhibitory polynucleotides. Within one embodiment of the invention the fibrosis is liver fibrosis.
Claims3
A method of reducing liver fibrosis caused by zvegf3 in a mammal, the method comprising administering to a mammal in need of said reducing a composition comprising a therapeutically effective amount of a zvegf3 antagonist in combination with a pharmaceutically acceptable delivery vehicle, wherein the zvegf3 antagonist is a monoclonal antibody that specifically binds to a zvegf3 dimeric protein consisting of two polypeptide chains, wherein each of said polypeptide chains consists of a sequence of amino acid residues as shown in SEQ ID NO:2 from amino acid residue X to amino acid residue 345, wherein X is an integer from 230 to 240, inclusive.
Dependencies are inferred from the claim text.