Liquid formulations for the prevention and treatment of mucosal diseases and disorders
AssigneeAccess Pharmaceuticals, Inc.
InventorsJeremy E. Jacob, David P. Nowotnik, Christiane M. Baud
Life of this patent
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Abstract
Stable, viscous, mucoadhesive aqueous compositions which are useful for the prevention and treatment of ulcerative, inflammatory, and/or erosive disorders of mucous membranes and/or the delivery of pharmaceutically active compounds to mucosal surfaces for topical treatment or transfer to the systemic circulation.
Claims18
A pseudoplastic liquid composition for treating or inhibiting an oral mucocutaneous disorder, said liquid composition having a zero shear viscosity at 37±1 degrees Celsius of 100-20,000 centipoise, comprising 0.1 to 3.0 wt/wt % of one or more mucoadhesives in an aqueous solution, wherein the mucoadhesive(s) is/are one or more linear or cross-linked polymer(s) selected from the group consisting of polyacrylic acid, carbopol, carboxymethylcellulose, hydroxyalkylcellulose, dextran sulfate, chitosan, and a water-soluble vinyl polymer;
- wherein said liquid composition, when administered to an oral mucosa:
- 1) remains liquid when shear is applied due to swishing the liquid in the mouth;
- and
- 2) attaches to and coats the oral mucosa upon discontinuance of said shear.
A pseudoplastic liquid composition for treating or inhibiting an oral mucocutaneous disorder, said liquid composition having a zero shear viscosity at 37±1 degrees Celsius of 100-20,000 centipoise, comprising 0.35 w/w % of one or more mucoadhesives in an aqueous solution, wherein the mucoadhesive(s) is/are one or more linear or cross-linked polymer(s) selected from the group consisting of polyacrylic acid, carbopol, carboxymethylcellulose, hydroxyalkylcellulose, dextran sulfate, chitosan, and a water-soluble vinyl polymer;
- wherein said liquid composition, when administered to an oral mucosa:
- 1) remains liquid when shear is applied due to swishing the liquid in the mouth;
- and
- 2) attaches to and coats the oral mucosa upon discontinuance of said shear.
A pseudoplastic liquid composition for treating or inhibiting an oral mucocutaneous disorder, said liquid composition having a zero shear viscosity at 37±1 degrees Celsius of 100-20,000 centipoise, comprising 0.35 w/w % of one or more mucoadhesives and 5 w/w % of a viscosity inducing agent in an aqueous solution;
- wherein said liquid composition, when administered to an oral mucosa:
- 1) remains liquid when shear is applied due to swishing the liquid in the mouth;
- and
- 2) attaches to and coats the oral mucosa upon discontinuance of said shear.
A pseudoplastic liquid composition for treating or inhibiting an oral mucocutaneous disorder, said liquid composition having a zero shear viscosity at 37±1 degrees Celsius of 100-20,000 centipoise, comprising 0.35 w/w % of cabopol, 1.5 w/w % of benzyl alcohol, 0.4 w/w % of sodium saccharin, and 0.05% w/w % of polysorbate 60 in an aqueous solution;
- wherein said liquid composition, when administered to an oral mucosa:
- 1) remains liquid when shear is applied due to swishing the liquid in the mouth;
- and
- 2) attaches to and coats the oral mucosa upon discontinuance of said shear.
Dependencies are inferred from the claim text.