Removable stent and method of using the same
AssigneeAlveolus, Inc.
InventorsGerard A. Silvestri, Lutz Freitag
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AssigneeAlveolus, Inc.
InventorsGerard A. Silvestri, Lutz Freitag
Estimating the term…
The present invention, in an exemplary embodiment, provides a stent, which combines many of the excellent characteristics of both silicone and metal stents while eliminating the undesirable ones. In particular, it is an objective of a preferred embodiment of the present invention to provide a stent that is easily installed, yet removable. Moreover, the stent does not cause material infections and has the capacity to reduce infection. Therefore, a principal objective of a preferred embodiment in accordance with the present invention is to provide a prosthesis that is suitable for both permanent and temporary use while being easy to insert, reposition and remove. This prosthesis is also suitable for targeted delivery of antimicrobial and chemotherapeutic agents. Additionally, a principal objective in accordance with the present invention is to provide a family of stents where the relative hardness/softness of regions of the stent can differ from other regions of the stent to provide additional patient comfort and resistance to radial forces. An exemplary embodiment also provides a family of stents with novel interstice configurations that facilitate flexibility, durability and/or proper installation.
A medical appliance for placement within and removal from a portion of the anatomy of a patient, the appliance comprising:
A medical appliance for placement within and removal from a portion of the anatomy of a patient, the appliance comprising:
A medical appliance for placement within and removal from a portion of the anatomy of a patient, the appliance comprising:
A method of treating a patient suffering from luminal irregularities, comprising the steps of:
A medical appliance for placement within and removal from a portion of the anatomy of a patient, the appliance comprising:
A method of treating a patient suffering from luminal irregularities, comprising the steps of:
Dependencies are inferred from the claim text.
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Made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes: with bands having a meander structure, adjacent bands being…
Characterised by a net-like or mesh-like structure: made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
Inorganic materials: metals or alloys
Antineoplastic agents
Term ended 10 Dec 2022 (estimated)
The present invention relates generally to medical devices directed to the prevention of nonvascular vessel or passageway occlusion, and more particularly to removable tracheal/bronchial stents and methods for utilizing these stents in the treatment of both benign and malignant conditions.
Stents are devices that are inserted into a vessel or passage to keep the lumen open and prevent closure due to a stricture, external compression, or internal obstruction. In particular, stents are commonly used to keep blood vessels open in the coronary arteries and they are frequently inserted into the ureters to maintain drainage from the kidneys, the bile duct for pancreatic cancer or cholangiocarcinoma or the esophagus for strictures or cancer.
In particular, airway stents are principally utilized for four indications, namely: (1) re-establishment of airway patency due to extrinsic tracheobronchial compression from either mass or lymph nodes; (2) re-establishment of airway patency due to intrinsic tracheobronchial obstruction from malignant or benign disease; (3) to cover a fistula track secondary to tracheo-esophageal fistula; and/or (4) to maintain airway patency in patients with tracheobronchial malacia. There are currently two basic types of stents available for some but not all of these indications: polymer or metal.
FIG. 1 shows an elevated side perspective view of an exemplary luminal stent in accordance with the present invention.
FIG. 2 shows a side perspective view of the luminal stent shown in FIG. 1.
FIG. 3 shows an aerial perspective view of interior of the luminal stent shown in FIG. 1.
A preferred embodiment of the stent, in accordance with the present invention, provides a removable stent that prevents epithelialization of the stent and is suitably configured to minimize infections and airway irritation. The exemplary stent is not subject to premature elongation and foreshortening but is capable of engaging the desire implantation location. The stent also retains its axial length while undergoing radial compression. Additionally, the stent has both antimicrobial and/or chemotherapeutic properties so that the stent can be indicated as an early stage therapy.
The term “antimicrobial agent” as used in the present invention means antibiotics, antiseptics, disinfectants and other synthetic moieties, and combinations thereof, that are soluble in organic solvents such as alcohols, ketones, ethers, aldehydes, acetonitrile, acetic acid, formic acid, methylene chloride and chloroform. Classes of antibiotics that can possibly be used include tetracyclines (i.e. minocycline), rifamycins (i.e. rifampin), macrolides (i.e. erythromycin), penicillins (i.e. nafcillin), cephalosporins (i.e. cefazolin), other beta-lactam antibiotics (i.e. imipenem, aztreonam), aminoglycosides (i.e. gentamicin), chloramphenicol, sulfonamides (i.e. sulfamethoxazole), glycopeptides (i.e. vancomycin), quinolones (i.e. ciprofloxacin), fusidic acid, trimethoprim, metronidazole, clindamycin, mupirocin, polyenes (i.e. amphotericin B), azoles (i.e. fluconazole) and beta-lactam inhibitors (i.e. sulbactam).
Examples of specific antibiotics that can be used include minocycline, rifampin, erythromycin, nafcillin, cefazolin, imipenem, aztreonam, gentamicin, sulfamethoxazole, vancomycin, ciprofloxacin, trimethoprim, metronidazole, clindamycin, teicoplanin, mupirocin, azithromycin, clarithromycin, ofloxacin, lomefloxacin, norfloxacin, nalidixic acid, sparfloxacin, pefloxacin, amifloxacin, enoxacin, fleroxacin, temafloxacin, tosufloxacin, clinafloxacin, sulbactam, clavulanic acid, amphotericin B, fluconazole, itraconazole, ketoconazole, and nystatin. Other examples of antibiotics, such as those listed in U.S. Pat. No. 4,642,104, herein incorporated by reference, will readily suggest themselves to those of ordinary skill in the art.