Methods for producing nateglinide B-type crystals
AssigneeAjinomoto Co., Inc.
InventorsMichito Sumikawa, Makoto Maruo, Kazuo Miyazaki, Shigehiro Nishina, Yukiko Matsuzawa
Life of this patent
Estimating the term…
Abstract
A method for producing B-type crystals of nateglinide substantially free of H-type crystals is provided, which comprises drying solvated wet crystals of nateglinide at a low temperature until no solvent remains and making a crystal conversion thereof. According to this method, B-type crystals of nateglinide can be produced at an industrial scale without allowing other forms of the crystalline polymorphism to coexist.
Claims24
A method for producing B-type crystals of nateglinide substantially free of H-type crystals, which comprises drying solvated wet crystals of nateglinide at a temperature of 50° C. or lower until 5% by weight or less of solvent remains and making a crystal conversion thereof by heating the resultant at 60 to 110° C.
A method for producing B-type crystals of nateglinide substantially free of H-type crystals, which comprises drying solvated materials containing nateglinide hydrates obtained by crystallizing out from a nateglinide-containing solution under cooling, at a temperature of 50° C. or lower until 5% by weight or less of solvent remains, and heating the resultant at a temperature of 60 to 110° C. to convert the crystal form of the resultant into B-type crystal.
Dependencies are inferred from the claim text.