Compositions for manipulating the lifespan and stress response of cells and organisms
AssigneesPresident and Fellows of Harvard College, BIOMOL International L.P.
InventorsDavid A. Sinclair, Konrad T. Howitz, Robert E. Zipkin, Kevin J. Bitterman, Dudley W. Lamming
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Abstract
Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.
Claims12
A method for increasing the deacetylase activity of SIRT1in a eukaryotic cell, comprising contacting a eukaryotic cell with a non-naturally occurring agent that binds SIRT1, reduces the Km of SIRT1 for substrate and thereby increases the deacetylase activity of SIRT1.
Dependencies are inferred from the claim text.