Asthma and allergic inflammation modulators

A method for treating a respiratory allergic disease or a disease or condition selected from group consisting of asthma, allergic rhinitis, eczema, psoriasis, atopic dermatitis, rheumatoid arthritis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, chronic obstructive pulmonary disease, conjunctivitis, nasal congestion and urticaria, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula (XVI):

• or a pharmaceutically acceptable salt thereof, wherein
• Y is —S(O)2—;
• X is —O—;
• R2 is a substituted or unsubstituted benzene ring;
• R3 and R5 are independently selected from the group consisting of hydrogen, halogen, (C1-C8)alkyl, fluoro(C1-C4)alkyl, hetero(C2-C8)alkyl, aryl, heteroaryl, aryl(C1-C4)alkyl, —NR′R″, —OR′, —NO2, —CN, —C(O)R′, —CO2R′, —C(O)NR′R″, —(C1-C4)alkylene-C(O)NR′R″, —S(O)mR′, —S(O)kNR′R″, —OC(O)OR′, —OC(O)R′, —OC(O)NR′R″, —N(R′″)C(O)NR′R″, —N(R″)C(O)R′ and —N(R″)C(O)OR′;
• R4 is selected from the group consisting of —NHC(O)-cyclo(C5-C7)alkyl, —C(O)NR12R13 and —NHC(O)-alkyl;
• R6 is selected from the group consisting of hydrogen, halogen, (C1-C8)alkyl, fluoro(C1-C4)alkyl, hetero(C2-C8)alkyl, aryl, heteroaryl, aryl(C1-C4)alkyl, —NR′R″, —NO2, —CN, —C(O)R′, —CO2R′, —C(O)NR′R″, —(C1-C4)alkylene-C(O)NR′R″, —S(O)mR′, —S(O)kNR′R″, —OC(O)OR′, —OC(O)R′, —OC(O)NR′R″, —N(R′″)C(O)NR′R″, —N(R″)C(O)R′ and —N(R″)C(O)OR′;
• R10 is selected from the group consisting of hydrogen, (C1-C8)alkyl, fluoro(C1-C4)alkyl, hetero(C2-C8)alkyl, aryl, heteroaryl, aryl(C1-C4)alkyl, —C(O)R′, —CO2R′, —C(O)NR′R″, —S(O)mR′ and —S(O)kNR′R″;
• L is a divalent linkage selected from the group consisting of a single bond, (C1-C6)alkylene and (C2-C4)heteroalkylene;
• Z is —CO2R12;
• R12 and R13 are independently selected from the group consisting of hydrogen, (C1-C8)alkyl, hetero(C2-C8)alkyl, aryl, aryl(C1-C4)alkyl and heteroaryl;
• each R14 is independently selected from the group consisting of halogen, (C1-C8)alkyl, fluoro(C1-C4)alkyl, —OR′, —NR′R″, —NO2, —CN, —C(O)R′ and aryl;
• each R′, R″ and R′″ is independently selected from the group consisting of hydrogen, (C1-C6)alkyl, cyclo(C3-C8)alkyl, aryl and aryl(C1-C4)alkyl;
• each subscript k is independently 0, 1 or 2;
• each subscript m is independently 0, 1, 2 or 3;
• and
• the subscript n is 0, 1, 2, 3 or 4.