Aryl carbonyl derivatives as therapeutic agents
AssigneeNovo Nordisk A/S
InventorsDharma Rao Polisetti, Janos Tibor Kodra, Jesper Lau, Paw Bloch, Mustafa Guzel, Kalpathy Chidambareswaran Santhosh, Adnan M. M. Mjalli, Robert Carl Andrews, Govindan Subramanian, Michael Ankersen, Per Vedso, Anthony Murray, Lone Jeppesen, Jesper Lau
Life of this patent
Estimating the term…
Abstract
This invention relates to aryl carbonyl derivatives which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
Claims22
A compound of Formula (Ib)
- wherein
- R24 is selected from the group consisting of F, Cl, Br, and —CH3;
- L1 is —C(O)—;
- G1 is selected from the group consisting of methyl, ethyl, propyl, butyl, isopropyl, isobutyl, cyclopentyl, cyclohexyl, tetrahydrofuranyl, tetrahydropyranyl, piperidyl, and hexahydroazepinyl;
- L2 is —N—(R20)—;
- R20 is H;
- L3 is —C(O)—;
- R1 is hydrogen;
- G2 is
- R43 is —C1-6-alkylene-C(O)OR54;
- R54 is hydrogen, methyl, ethyl, propyl, butyl, isopropyl, isobutyl, sec-butyl, tert-butyl, 3-pentyl, 2-pentyl, or 3-methyl-butyl;
- or a pharmaceutically acceptable salt or solvate thereof.
The compound {2-[3-(2-cyclopentanecarbonyl-4-methyl-phenyl)-ureido]-thiazol-4-yl} acetic acid or a pharmaceutically acceptable salt or solvate thereof.
A pharmaceutical composition comprising the compound of Formula (Ib)
- wherein
- R24 is selected from the group consisting of F, Cl, Br, and —CH3;
- L1 is —C(O)—;
- G1 is selected from the group consisting of methyl, ethyl, propyl, butyl, isopropyl, isobutyl, cyclopentyl, cyclohexyl, tetrahydrofiaranyl, tetrahydropyranyl, piperidyl, and hexahydroazepinyl;
- L2 is —N—(R20)—;
- R20 is H;
- L3 is —C(O)—;
- R1 is hydrogen;
- G2 is
- R43 is —C1-6-alkylene-C(O)OR54;
- R54 is hydrogen, methyl, ethyl, propyl, butyl, isopropyl, isobutyl, sec-butyl, tert-butyl, 3-pentyl, 2-pentyl, or 3-methyl-butyl;
- or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, diluent, excipient, or mixture thereof.
A pharmaceutical composition comprising the compound {2-[3-(2-cyclopentanecarbonyl-4-methyl-phenyl)-ureido]-thiazol-4-yl} acetic acid or a pharmaceutically acceptable salt or solvate thereof and a pharmaceutically acceptable carrier, diluent, excipient, or mixture thereof.
Dependencies are inferred from the claim text.