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US 7,541,140 B2Granted
Assessing risk for kidney stones using parathyroid hormone agonist and antagonist
AssigneeScantibodies Laboratory, Inc.
InventorThomas L. Cantor
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Abstract
The present invention relates to identifying the risk of a subject developing renal stones utilizing an assessment of PTH agonist, antagonist and/or total PTH levels, optionally together with an assessment of serum and/or urine calcium levels and/or other analytes. The present description further relates to monitoring and guiding treatment for renal stones and kits useful therefore.
Claims14
A method for determining the risk of a subject for developing renal calcium calculi comprising:
- a) determining the level of parathyroid hormone (PTH) agonist and the level of PTH antagonist in a sample obtained from a subject;
- b) comparing the level of PTH agonist and PTH antagonist in the sample in a ratio;
- and
- c) determining the risk for developing renal calcium calculi in the subject based on the ratio;
- wherein the PTH agonist is a peptide having an amino acid sequence of human 1-84 PTH (SEQ ID NO:1);
- and the PTH antagonist is-7-84 PTH (SEQ ID NO:7).
3 more elements
Dependencies are inferred from the claim text.