Comparative mycobacterial geneomics as a tool for identifying targets for the diagnosis, prophylaxis or treatment of mycobacterioses
AssigneeInstitut Pasteur
InventorStewart Cole
Life of this patent
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Abstract
The present invention is directed to a method of selection of purified nucleotidic sequences or polynucleotides encoding proteins or part of proteins carrying at least an essential function for the survival or the virulence of mycobacterium species by a comparative genomic analysis of the sequence of the genome of M. tuberculosis aligned on the genome sequence of M. leprae and M. tuberculosis and M. leprae marker polypeptides of nucleotides encoding the polypeptides, and methods for using the nucleotides and the encoded polypeptides are disclosed.
Claims6
A recombinant bacterial artificial chromosome (BAC) comprising SEQ ID NO:
- 645, SEQ ID NO:
- 646, SEQ ID NO:
- 647, SEQ ID NO:
- 648, or SEQ ID NO:
- 649.
A recombinant cosmid comprising SEQ ID NO:
- 650 or SEQ ID NO:
- 651.
A recombinant purified vector comprising SEQ ID NO:
- 645, SEQ ID NO:
- 646, SEQ ID NO:
- 647, SEQ ID NO:
- 648, SEQ ID NO:
- 649, SEQ ID NO:
- 650, or SEQ ID NO:
- 651.
Dependencies are inferred from the claim text.