MATER-protein specific antibodies and methods of use
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsLawrence M. Nelson, Zhi-Bin Tong
Life of this patent
Estimating the term…
Abstract
Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human Mater cDNA and protein sequences are provided. Functional MATER is required for female fertility; zygotes that arise from Mater null oocytes do not progress beyond the two-cell stage. MATER-protein specific binding agents, such as antibodies, are described. Methods are described for detecting MATER protein in a subject, including methods for determining whether a subject has a biological condition associated with abnormal Mater expression. Also provided are kits for detecting MATER protein in a subject.
Claims8
An isolated MATER-protein specific binding agent comprising an antibody or functional fragment thereof, which antibody or functional fragment recognizes an epitope of the amino acid sequence shown in SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.