PPAR active compounds

A compound having the chemical structure

• pharmaceutically acceptable salts, tautomers and steroisomers thereof,
• wherein:
• Q is —O—, —S—, or —NR51—;
• R1 is selected from the group consisting of optionally substituted carboxyl and a carboxylic acid isostere;
• R3 and R4 are independently selected from the group consisting of hydrogen, optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycloalkyl, optionally substituted heterocycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, and optionally substituted heteroaralkyl,or R3 and R4 may combine to form a 3-7 membered optionally substituted mono-cycloalkyl or 3-7 membered optionally substituted mono-heterocycloalkyl;
• R5 is independently selected from the group consisting of hydrogen, halo, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycloalkyl, optionally substituted heterocycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, —OR10, —SR11, —NR12R13, —C(Z)NR6R7, —C(Z)R8, —S(O)2NR6R7, and —S(O)nR9;
• R6 and R7 at each occurrence are independently selected from the group consisting of hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, provided, however, that when R6 and/or R7 are optionally substituted lower alkenyl, no alkene carbon thereof is bound to nitrogen, optionally substituted lower alkynyl provided, however, that when R6 and/or R7 are optionally substituted lower alkynyl, no alkyne carbon thereof is bound to nitrogen, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycloalkyl, optionally substituted heterocycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, and optionally substituted heteroaralkyl, or R6 and R7 together with the nitrogen to which they are attached form a 5-7 membered optionally substituted heterocycloalkyl or 5-7 membered optionally substituted heteroaryl;
• R8 at each occurrence is independently selected from the group consisting of optionally substituted lower alkyl, optionally substituted lower alkenyl, provided, however, that when R8 is optionally substituted lower alkenyl, no alkene carbon thereof is bound to —C(Z)-, optionally substituted lower alkynyl, provided, however, that when R8 is optionally substituted lower alkynyl, no alkyne carbon thereof is bound to —C(Z)-, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycloalkyl, optionally substituted heterocycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, and —OR11;
• R9 at each occurrence is independently selected from the group consisting of optionally substituted lower alkyl, optionally substituted lower alkenyl, provided, however, that when R9 is optionally substituted lower alkenyl, no alkene carbon thereof is bound to —S(O)n—, optionally substituted lower alkynyl, provided, however, that when R9 is optionally substituted lower alkynyl, no alkyne carbon thereof is bound to —S(O)n—, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycloalkyl, optionally substituted heterocycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, and optionally substituted heteroaralkyl;
• R10 at each occurrence is independently selected from the group consisting of hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, provided, however, that when R10 is optionally substituted lower alkenyl, no alkene carbon thereof is bound to oxygen, optionally substituted lower alkynyl, provided, however, that when R10 is optionally substituted lower alkynyl, no alkyne carbon thereof is bound to oxygen, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycloalkyl, optionally substituted heterocycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, —C(Z)R8, and —C(Z)NR6R7;
• R11 at each occurrence is independently selected from the group consisting of hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, provided, however, that when R11 is optionally substituted lower alkenyl, no alkene carbon thereof is bound to S or O, optionally substituted lower alkynyl, provided, however, that when R11 is optionally substituted lower alkynyl, no alkyne carbon thereof is bound to S or O, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycloalkyl, optionally substituted heterocycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, and optionally substituted heteroaralkyl;
• R12 and R13 at each occurrence are independently selected from the group consisting of hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, provided, however, that when R12 and/or R13 are optionally substituted lower alkenyl, no alkene carbon thereof is bound to nitrogen, optionally substituted lower alkynyl, provided, however, that when R12 and/or R13 are optionally substituted lower alkynyl, no alkyne carbon thereof is bound to nitrogen, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycloalkyl, optionally substituted heterocycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, —C(Z)R8, —C(Z)NR6R7, —S(O)2R9, and —S(O)2NR6R7, or R12 and R13 together with the nitrogen to which they are attached form a 5-7 membered optionally substituted heterocycloalkyl or 5-7 membered optionally substituted heteroaryl;
• R15 is selected from the group consisting of hydrogen, halo, cyano, nitro, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, —OR10, —SR11, —NR12R13, —C(Z)NR6R7, —C(Z)R8, —S(O)2NR6R7, and —S(O)nR9,attached to A at any available atom to produce a stable compound;
• R16 at each occurrence is independently selected from the group consisting of halo, lower alkyl, hydroxyl, lower alkoxy, thiol, and lower alkylthio, wherein lower alkyl and the lower alkyl chains of lower alkoxy and lower alkylthio are optionally substituted with fluoro, hydroxyl, lower alkoxy, thiol, or lower alkylthio, provided, however, that any substitution on lower alkoxy or lower alkylthio does not result in O or S bound to the carbon that is bound to the alkoxy oxygen of substituted lower alkoxy or the alkylthio sulfur of substituted lower alkylthio;
• A is a monocyclic or bicyclic ring selected from the group consisting of cycloalkyl, heterocycloalkyl, aryl or heteroaryl;
• L is —S(O)2NR56— or —S(O)2—, attached to A at any available atom to produce a stable compound;
• R51 is selected from the group consisting of hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, provided, however, that when R51 is optionally substituted lower alkenyl, no alkene carbon thereof is bound to nitrogen, optionally substituted lower alkynyl, provided, however, that when R51 is optionally substituted lower alkynyl, no alkyne carbon thereof is bound to nitrogen, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycloalkyl optionally substituted heterocycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, —C(Z)NR6R7, —C(Z)R8, —S(O)2NR6R7, and —S(O)2R9;
• R54 and R55 are independently lower alkyl or combine with the nitrogen to which they are attached to form a 5-7 membered heterocycloalkyl or 5-7 membered heterocycloalkyl substituted with halo, hydroxyl, lower alkoxy, or lower alkyl;
• R56 is selected from the group consisting of hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, provided, however, that when R56 is optionally substituted lower alkenyl, no alkene carbon thereof is bound to nitrogen, optionally substituted lower alkynyl, provided, however, that when R56 is optionally substituted lower alkynyl, no alkyne carbon thereof is bound to nitrogen, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycloalkyl, optionally substituted heterocycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, and optionally substituted heteroaralkyl;
• m is 0, 1, or 2;
• n is 1 or 2;
• and
• Z is O or S.