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AssigneesMedImmune, LLC, ViroNovative BV
InventorsRonaldus Adrianus Maria Fouchier, Bernadetta Gerarda Van Den Hoogen, Albertus Dominicus Marcellinus Erasmus Osterhaus, Aurelia Haller, Roderick Tang
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The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae , of the family Paramyxoviridae . The invention also provides isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular the invention provides a mammalian MPV, subgroups and variants thereof. The invention relates to genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The invention relates to the use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods. The present invention relates to nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus. The invention further encompasses chimeric or recombinant viruses encoded by said nucleotide sequences. The invention also relates to chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. The invention further relates to vaccine formulations comprising mammalian or avian metapneumovirus, including recombinant and chimeric forms of said viruses. The vaccine preparations of the invention encompass multivalent vaccines, including bivalent and trivalent vaccine preparations.
An isolated negative-sense single stranded RNA virus MPV belonging to the sub-family Pneumovirinae of the family Paramyxoviridae and identifiable as phylogenetically corresponding to the genus Metapneumovirus, wherein the virus is a human virus wherein the amino acid sequence of the N protein of the virus is at least 90% identical to SEQ ID NO:366.
An isolated negative-sense single stranded RNA virus human MPV belonging to the sub-family Pneumovirinae of the family Paramyxoviridae and identifiable as phylogenetically corresponding to the genus Metapneumovirus, wherein the N protein of the virus is phylogenetically more closely related to the N protein of a virus isolate deposited as I-2614 with CNCM, Paris than to the N protein of the turkey rhinotracheitis virus, the etiological agent of avian rhinotracheitis.
An isolated negative-sense single stranded RNA virus human MPV belonging to the sub-family Pneumovirinae of the family Paramyxoviridae and identifiable as phylogenetically corresponding to the genus Metapneumovirus, wherein the N protein of the virus is phylogenetically more closely related to the N protein of a virus isolate deposited as I-2614 with CNCM, Paris than to the N protein of APV type C.
An isolated negative-sense single stranded RNA virus human MPV belonging to the sub-family Pneumovirinae of the family Paramyxoviridac and identifiable as phylogenetically corresponding to the genus Metapneumovirus, wherein the N protein of the virus is phylogenetically more closely related to the N protein of a virus isolate comprising the nucleotide sequence of SEQ ID NO:19 than it is related to the N protein of turkey rhinotracheitis virus, the etiological agent of avian rhinotracheitis.
An isolated negative-sense single stranded RNA metapneumovirus, wherein
An isolated negative-sense single stranded RNA metapneumovirus, wherein (i) the metapneumovirus belongs to the subfamily Pneumovirinae of the family Paramyxoviridae;
An isolated negative-sense single stranded RNA human metapneumovirus, wherein the genome of the virus comprises a nucleotide sequence of SEQ ID NO:19.
Dependencies are inferred from the claim text.