Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
AssigneeBiomarin Pharmaceutical Inc.
InventorsMichel Claude Vellard, Paul Andrew Fitzpatrick, Emil D. Kakkis
Life of this patent
Estimating the term…
Abstract
The present invention is directed to phenylalanine ammonia lyase (PAL) produced by prokaryotes, wherein such prokaryotic PAL wherein the PAL variant has a greater phenylalanine-converting activity as compared to a wild-type PAL. The invention thus provides compositions of bacterial PAL and biologically active fragments, mutants, variants and analogs thereof, as well as methods for the production, purification, and use of such compositions for therapeutic and industrial purposes.
Claims6
A wild-type Anabaena variabilis phenylalanine ammonia lyase comprising a polyethylene glycol.
A wild-type Nostoc punctiforme phenylalanine ammonia lyase comprising a polyethylene glycol.
Dependencies are inferred from the claim text.