Methods of enhancing radiation effects with metal nanoparticles
AssigneeNanoprobes, Inc.
InventorsJames F. Hainfeld, Daniel N. Slatkin
Life of this patent
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Abstract
The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue, such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.
Claims43
A method of enhancing the effects of radiation directed to a tissue or a population of cells in an animal comprising administering an amount of metal nanoparticles to said animal and subsequently irradiating the animal with radiation directed to said tissue or said population of cells, wherein said radiation is in a form selected from the group consisting of x-rays, microbeam arrays of x-rays, radioisotopes, electrons, protons, ion beams, and neutrons, wherein said metal nanoparticles are administered to said animal in an amount to achieve a concentration in said tissue or said population of cells in the animal of at least about 0.1% metal by weight.
A method of ablating a tissue or a population of cells in an animal comprising administering an amount of metal nanoparticles to said animal and subsequently irradiating the animal with radiation directed to said tissue or said population of cells, wherein said radiation is in a form selected from the group consisting of x-rays, microbeam arrays of x-rays, radioisotopes, electrons, protons, ion beams, and neutrons , wherein said metal nanoparticles are administered to said animal in an amount to achieve a concentration in said tissue or said population of cells in the animal of at least about 0.1% metal by weight.
A method of enhancing the effects of radiation directed to a tissue or a population of cells in an animal comprising administering an amount of metal nanoparticles to said animal and subsequently irradiating the animal with radiation directed to said tissue or said population of cells, wherein said metal nanoparticles are administered to said animal in an amount to achieve a concentration of metal in said tissue or said population of cells in the animal of at least about 0.1% by weight.
A method of enhancing the effects of radiation directed to a tissue or a population of cells in an animal comprising administering an amount of metal nanoparticles to said animal and subsequently irradiating the animal with radiation directed to said tissue or said population of cells, wherein said metal nanoparticles comprise a surface layer material which comprises thioglucose.
A method of enhancing the effects of radiation directed to a tissue or a population of cells in an animal comprising administering an amount of metal nanoparticles to said animal and subsequently irradiating the animal with radiation directed to said tissue or said population of cells, wherein said nanoparticles are polyanions of metals complexed with quatemary ammonium salts.
Dependencies are inferred from the claim text.