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US 7,528,255 B2Granted
Hydroxy, ω-carboxyaryl substituted diphenyl ureas and dirivatives thereof as raf kinase inhibitors
AssigneeBayer Pharmaceuticals Corporation
InventorsBernd Riedl, Jacques Dumas, Uday Khire, Timothy Lowinger, William Scott, Roger Smith, Jill Wood
Life of this patent
Estimating the term…
Abstract
The invention relates to the use of a group of aryl ureas in treating raf mediated diseases and pharmaceutical compositions for use in such therapy of the formula wherein, Y is NHR Hal is chlorine or bromine, R is H, CH3 or CH2OH, and X1 to X7 are each, independently, H, OH or —OC(O)C1-C4 alkyl, or a salt purified stereoisomer thereof, wherein at least one of X1 to X7 is OH or —OC(O)C1-C4 alkyl.
Claims15
A compound of formula (Ia)
- wherein,
- Y is NHR,
- Hal is chlorine or bromine,
- R is H, CH3 or CH2OH, and
- X1 to X7 are each, independently, H, OH or —OC(O)C1-C4 alkyl,
- or a salt or purified stereoisomer thereof,
- with the proviso that at least one of X1 to X7 is OH or —OC(O)C1-C4 alkyl.
4 more elements
A compound of formula (Ib)
- wherein,
- Y is NHR,
- Hal is chlorine or bromine,
- R is H, CH3 or CH2OH, and
- X4 to X7 are each, independently, H, OH or —OC(O)C1-C4 alkyl,
- or a salt or purified stereoisomer thereof,
- with the proviso that at least one of X4 to X7 is OH or —OC(O)C1-C4 alkyl.
4 more elements
A compound of formula (Ic)
- wherein,
- Hal is chlorine or bromine, and
- X1 to X7 are each, independently, H, OH or —OC(O)C1-C4 alkyl,
- or a salt or purified stereoisomer thereof,
- with the proviso that at least one of X1 to X7 is OH or —OC(O)C1-C4 alkyl.
2 more elements
Dependencies are inferred from the claim text.