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US 7,527,951 B2Granted
Engineering fungi for the utilisation of L-arabinose
AssigneeValtion Teknillinen Tutkimuskeskus
InventorsJohn Londesborough, Merja Penttilä, Peter Richard
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Abstract
A fungal microorganism can be engineered by means of genetic engineering to utilise L-arabinose. The genes of the L-arabinose pathway, which were unknown, i.e. L-arabinitol 4-dehydrogenase and L-xylulose reductase, were identified. These genes, together with the known genes of the L-arabinose pathway, form a functional pathway. This pathway can be introduced to a fungus, which is completely or partially lacking this pathway.
Claims1
A method of producing a useful product from biomass containing L-arabinose, which comprises:
- (a) providing a genetically modified fungus which is transformed with a DNA encoding an enzyme selected from the group consisting of L-arabinitol 4-dehydrogenase (LA4D) and L-xylulose reductase (LXR), each of the fungal L-arabinose pathway, wherein said fungus has an increased ability to utilize L-arabinose;
- and
- (b) fermenting said fungus under conditions suitable to produce said useful product,
- wherein the DNA is selected from the group consisting of SEQ ID NO. 1, and SEQ ID NO. 2.
1 more element
Dependencies are inferred from the claim text.