Regeneration and repair of neural tissue using postpartum-derived cells
AssigneeEthicon, Inc.
InventorsDarin J. Messina, Sanjay Mistry, Alexander M. Harmon, Ian Ross Harris, Anthony J. Kihm, Agnieszka Seyda, Chin-Feng Yi
Life of this patent
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Abstract
Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.
Claims17
A method of treating a patient having nerve pathology caused by traumatic nerve injury, said method comprising administering to the patient one or more cells, wherein said one or more cells are isolated from human postpartum umbilical cord substantially free of blood or are expanded in culture from a cell isolated from human postpartum umbilical cord substantially free of blood, in an amount effective to treat the nerve pathology, wherein said one or more cells self-renew and expand in culture and have the potential to differentiate into cells of at least a neural phenotype;
- require L-valine for growth;
- can grow in at least about 5% oxygen;
- do not produce CD117;
- and exhibit increased expression, relative to a human fibroblast or mesenchymal stem cell, of an endogenous gene encoding oxidized low density lipoprotein receptor 1, interleukin 8, or reticulon 1.
Dependencies are inferred from the claim text.