Microprocessors, devices and methods for use in analyte monitoring systems

A method of obtaining an analyte value in biological fluid of a user with an analyte sensor having two electrode sets, the method comprising:

• contacting the two electrode sets with biological fluid of a user, in which each electrode set includes an iontophoretic electrode and an electrochemical sensor element in contact with the biological fluid and each of the two iontophoretic electrodes function as either a cathode or anode while in contact with the fluid;
• measuring a current signal at each of the anode and cathode;
• measuring a current signal related to the analyte from the sensor element associated with a cathode at each half-measurement cycle;
• determining, via the microprocessor, baseline current signal for a given sensor in which the iontophoretic electrode functions as a cathode based on the last two data points of the current signals from the given sensor in a previous half-cycle in which the given sensor is associated with an anode;
• subtracting, via the microprocessor, the background baseline current from the current signal related to the analyte;
• integrating, via the microprocessor, the current signal related to the analyte over time;
• upon over subtraction of the current signal related to the analyte, recalculating a background baseline current based on the last two data points from the current related to the analyte at the cathode;
• subtracting, via the microprocessor, the recalculated background baseline current from the current related to the analyte;
• integrating, via the microprocessor, the background subtracted current signal over time to obtain the charge signal as being proportional to a value of the analyte;
• and
• displaying, via the microprocessor, the analyte value of the biological fluid of the user for diagnostic purposes.