Anti-infective agents

A compound, a stereoisomer of the compound, a tautomer of the compound, a pharmaceutically acceptable salt of the compound, stereoisomer, or tautomer, or a combination thereof, wherein:

• the compound corresponds to formula (I):
• A is phenyl;
• R1 is selected fro the group consisting of —ORA, —O-alkyl-C(O)Y, —NRARB, —N(RC)(—N(RC)(RA)), —N(RB)L1(O)Y, and —N(RB)S(O)2Z;
• X at each occurrence, is independently selected from the group consisting of RA, —ORA and —NRARB;
• L1 is selected from the group consisting of a bond or lower alkyl;
• Y is selected from the group consisting of RA, —ORA, —NRARB, —O-alkyl-ORA, —O-alkyl-NRARB, —N(RC)-alkyl-NRARB, —(CR3R4)—N(RC)C(O)X;
• —(CR3R4)—NRARB, and heterocycle;
• Z is selected from the group consisting of RA, —ORA, —NRARB, -alkyl-ORA, -alkyl-NRARB, -alkyl-N(RC)C(O)X, -alkyl-O-alkyl-ORA, -alkyl-O-alkyl-NRARB and -alkyl-N(RC)-alkyl-NRARB;
• R3 and R4are independently selected from the group consisting of hydrogen, alkyl, alkenyl and arylalkyl wherein:
• the aryl moiety of the arylalkyl is substituted with 0, 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, formyl, halo, nitro, cyano, alkoxy, —OH, —OC(O)(alkyl), —SH, —S(alkyl), —S(O)alkyl, —S(O)2(alkyl), —NH2, —N(H)(alkyl), —N(alkyl)2, —C(O)alkyl, —C(O)OH, —C(O)(—Oalkyl), —C(O)NH2, —C(O)N(H)(alkyl), —C(O)N(alkyl)2 and haloalkyl;
• RA at each occurrence is independently selected from the group consisting of hydrogen, alkyl, alkenyl, haloalkyl, haloalkenyl, Ra and -alkylRa;
• RB at each occurrence is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, Ra, -alkylRa, —OH, alkoxy, hydroxyalkyl, alkoxyalkyl, —ORa, and —O-alkylRa;
• RC at each occurrence is independently selected from the group consisting of hydrogen and lower alkyl;
• Ra at each occurrence is independently selected from the group consisting of cycloalkyl, cycloalkenyl, heterocycle, aryl and heteroaryl, wherein:
• each such substituent is substituted with 0, 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, formyl, halo, nitro, cyano, alkoxy, —OH, —O-alkyl-Rb, —OC(O)(alkyl), —SH, —S(alkyl), —S(O)alkyl, —S(O)2(alkyl), —NH2, —N(H)(alkyl), —N(alkyl)2, —C(O)alkyl, —C(O)OH, —C(O)(—Oalkyl), —C(O)NH2, —C(O)N(H)(alkyl), —C(O)N(alkyl)2, haloalkyl, Rb and -alkyl-Rb;
• Rb at each occurrence is independently selected from the group consisting of cycloalkyl, cycloalkenyl, heterocycle, aryl and heteroaryl, wherein:
• each such substituent is substituted with 0, 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, formyl, halo, nitro, cyano, alkoxy, —OH, —OC(O)(alkyl), —SH, —S(alkyl), —S(O)alkyl, —S(O)2(alkyl), —NH2, —N(H)(alkyl), —N(alkyl)2, —C(O)alkyl, —C(O)OH, —C(O)(—Oalkyl), —C(O)NH2, —C(O)N(H)(alkyl), —C(O)N(alkyl)2 and haloalkyl;
• R2 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, Ra, -alkyl-Ra, -alkenyl-Ra, -alkynyl-Ra, haloalkyl, hydroxyalkyl, formylalkyl, cyanoalkyl, -alkyl-ORA, and -alkyl-NRARB;
• R5, R6, R7 , and R8 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cyano, formyl, halo, nitro, —ORA, —OC(O)RA, —OC(O)ORA, —OC(O)NRARB, —OS(O)2RA, —SRA, —S(O)RA, —S(O)2RA, —S(O)2(ORA), —S(O)2NRARB, —NRARB, —N(RC)C(O)RA, —N(RC)C(O)NRARB, —N(RC)C(O)ORA, —N(RC)S(O)2RA, —N(RC)S(O)2NRARB, —N(RC)S(O)2N(RC)C(O)ORA, —C(O)RA, —C(O)ORA, —C(O)NRARB, haloalkyl, cyanoalkyl, -alkylORA, -alkyl-OC(O)RA, -alkyl-OC(O)ORA, -alkyl-OC(O)NRARB, -alkyl-OS(O)2RA, -alkyl-SRA, -alkyl-S(O)RA, -alkyl-S(O)2RA, -alkyl-S(O)2(ORA), -alkyl-S(O)2NRARB, -alkyl-NRARB, -alkyl-N(RC)C(O)RA, -alkyl-N(RC)C(O)NRARB, -alkyl-N(RC)C(O)ORA, -alkyl-N(RC)S(O)2RA, -alkyl-N(RC)S(O)2NRARB, -alkyl-N(RC)S(O)2N(RC)C(O)ORA, -alkyl-C(O)RA, -alkyl-C(O)(ORA) and -alkyl-C(O)NRARB;
• R9 is selected from the group consisting of —ORA, —SRA, —NRARB, —N(RC)C(O)RA, —N(RC)C(O)ORA, —N(RC)S(O)2RA , and —N(RC)S(O)2NRARB;
• n is 0, 1, 2, 3 or 4;
• R10 at each occurrence is independently selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, formyl, nitro, halo, Ra, —ORA, —OC(O)X, —OS(O)2RA, —O-alkyl-G1, —SRA, —S(O)RA, —S(O)2X, —NRARB, —N(RB)C(O)X, —N(RB)C(O)(-alkyl-G1), —N(RB)S(O)2X, —N(RB)S(O)2(-alkyl-G1), —C(O)X, —C(O)N(RB)(-alkyl-G1), haloalkyl, cyanoalkyl, nitroalkyl, -alkyl-Ra, —N(-alkyl-C(O)X)(S(O)2X,) and -alkyl-G1;
• G1 at each occurence is independently selected from the group consisting of —ORA, —NRARB, —N(RC)(—NRARB), —N(RC)S(O)2X, —N(RC)C(O)X, —C(O)X, —OC(O)X, and —S(O)2X;
• and
• R11 is selected from the group consisting of hydrogen, alkyl, alkenyl and arylalkyl, wherein:
• the aryl moiety of the arylalkyl is substituted with 0, 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of
• alkyl, alkenyl, alkynyl, formyl, halo, nitro, cyano, haloalkyl, —OH, alkoxy, —OC(O)(alkyl), —NH2, —N(H)(alkyl), —N(alkyl)2, —C(O)OH, —C(O)(—Oalkyl), —C(O)alkyl, —C(O)NH2, —C(O)N(H)(alkyl), and —C(O)N(alkyl)2.