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US 7,515,954 B2Granted
Non-contact cardiac mapping, including moving catheter and multi-beat integration
AssigneeRhythmia Medical, Inc.
InventorsDoron Harlev, Pavel Greenfield, Leon Amariglio
Life of this patent
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Abstract
A non-contact cardiac mapping method is disclosed that includes: (i) inserting a catheter into a heart cavity having an endocardium surface, the catheter including multiple, spatially distributed electrodes; (ii) measuring signals at the catheter electrodes in response to electrical activity in the heart cavity with the catheter spaced from the endocardium surface; and (iii) determining physiological information at multiple locations of the endocardium surface based on the measured signals and positions of the electrodes with respect to the endocardium surface. Related systems and computer programs are also disclosed.
Claims59
A method comprising:
- inserting a catheter into a heart cavity having an endocardium surface, the catheter comprising multiple, spatially distributed electrodes;
- moving the catheter to each of multiple, different positions in the heart cavity for which the catheter is spaced from the endocardium surface;
- for each of the different catheter positions, determining the positions of the catheter electrodes with respect to the endocardium surface and measuring signals at the catheter electrodes in response to electrical activity in the heart cavity;
- and
- determining physiological information at multiple locations of the endocardium surface based on the determined positions of the catheter electrodes and the measured signals at the different catheter positions;
- wherein
- the signals are measured for at least one electrical heart cycle for each catheter position;
- the determination of the physiological information at the multiple locations of the endocardium surface comprises synchronizing the signals measured at the different catheter positions with one another according to an electrical heart beat cycle;
- and
- the determination of the physiological information at the multiple locations of the endocardium surface further comprises processing the synchronized signals as though they were obtained at one time from all of the positions sampled by the catheter electrodes for the different positions of the catheter in the heart cavity.
7 more elements
A method comprising:
- inserting a catheter into a heart cavity having an endocardium surface, the catheter comprising multiple, spatially distributed electrodes;
- moving the catheter to each of multiple, different positions in the heart cavity for which the catheter is spaced from the endocardium surface;
- for each of the different catheter positions, determining the positions of the catheter electrodes with respect to the endocardium surface and measuring signals at the catheter electrodes in response to electrical activity in the heart cavity;
- and
- determining physiological information at multiple locations of the endocardium surface based on the determined positions of the catheter electrodes and the measured signals at the different catheter positions;
- wherein the determination of the physiological information at the multiple locations of the endocardium surface comprises determining multiple estimates of the physiological information for each of at least some of the locations on the endocardium based on the measured signals corresponding to at least some of the different catheter positions.
3 more elements
A system comprising:
- a catheter configured to be inserted into a heart cavity having an endocardium surface and to move to each of multiple positions in the heart cavity for which the catheter is spaced from the endocardium surface, the catheter comprising multiple, spatially distributed electrodes, the multiple electrodes configured to measure signals in response to electrical activity in the heart cavity;
- a sensor device configured to determine, for each of the different catheter positions, the positions of the catheter electrodes with respect to the endocardium surface;
- a processing unit configured to determine physiological information at multiple locations of the endocardium surface based on the determined positions of the catheter electrodes and the measured signals at the different catheter positions;
- and
- a synchronization unit configured to synchronize the signals measured at the different catheter positions with one another according to an electric heart beat cycle.
2 more elements
A method comprising:
- inserting a catheter into a heart cavity having an endocardium surface, the catheter comprising multiple, spatially distributed electrodes;
- measuring signals at the catheter electrodes in response to electrical activity in the heart cavity with the catheter spaced from the endocardium surface;
- and
- determining physiological information at multiple locations of the endocardium surface based on the measured signals and positions of the electrodes with respect to the endocardium surface;
- wherein the signals are measured during multiple electrical heart beat cycles and wherein the physiological information is determined, at least in part, by combining information derived from the signals for different heart beat cycles;
- wherein the combining comprises integrating information derived from the signals for common phases of the electrical heart beat cycles.
3 more elements
A system comprising:
- a catheter configured to be inserted into a heart cavity having an endocardium surface, the catheter comprising multiple, spatially distributed electrodes, the multiple electrodes configured to measure signals in response to electrical activity in the heart cavity with the catheter spaced from the endocardium surface;
- and
- a processing unit configured to determine physiological information at multiple locations of the endocardium surface based on the measured signals and the position of the electrodes with respect to the endocardium surface;
- wherein the signals are measured during multiple electrical heart beat cycles and wherein the processing unit configured to determine physiological information is further configured to, at least in part, combine information derived from the signals for different heart beat cycles;
- and
- wherein the processing unit configured to combine information is further configured to integrate information derived from the signals for common phases of the electrical heart beat cycles.
3 more elements
A method comprising:
- inserting a catheter into a heart cavity having an endocardium surface, the catheter comprising multiple, spatially distributed electrodes;
- moving the catheter to each of multiple, different positions in the heart cavity for which the catheter is spaced from the endocardium surface;
- for each of the different catheter positions, determining the positions of the catheter electrodes with respect to the endocardium surface and measuring signals at the catheter electrodes in response to electrical activity in the heart cavity;
- determining physiological information at multiple locations of the endocardium surface based on the determined positions of the catheter electrodes and the measured signals at the different catheter positions;
- wherein
- the signals are measured for at least one electrical heart cycle for each catheter position;
- the determination of the physiological information at the multiple locations of the endocardium surface comprises synchronizing the signals measured at the different catheter positions with one another according to an electrical heart beat cycle;
- and
- the determination of the physiological information at the multiple locations of the endocardium surface further comprises applying a transformation function to the synchronized signals, wherein the transformation function relates signals measured from at least some of the different positions of the catheter in the heart cavity to the physiological information at the multiple locations of the endocardium surface.
6 more elements
A system comprising:
- a catheter configured to be inserted into a heart cavity having an endocardium surface and to move to each of multiple positions in the heart cavity for which the catheter is spaced from the endocardium surface, the catheter comprising multiple, spatially distributed electrodes, the multiple electrodes configured to measure signals in response to electrical activity in the heart cavity;
- a sensor device configured to determine, for each of the different catheter positions, the positions of the catheter electrodes with respect to the endocardium surface;
- and
- a processing unit configured to determine physiological information at multiple locations of the endocardium surface based on the determined positions of the catheter electrodes and the measured signals at the different catheter positions;
- wherein the processing unit is further configured to apply a transformation function to the synchronized signals, wherein the transformation function relates signals measured from at least some of the different positions of the catheter in the heart cavity to the physiological information at the multiple locations of the endocardium surface.
2 more elements
A system comprising:
- a catheter configured to be inserted into a heart cavity having an endocardium surface and to move to each of multiple positions in the heart cavity for which the catheter is spaced from the endocardium surface, the catheter comprising multiple, spatially distributed electrodes, the multiple electrodes configured to measure signals in response to electrical activity in the heart cavity;
- a sensor device configured to determine, for each of the different catheter positions, the positions of the catheter electrodes with respect to the endocardium surface;
- and
- a processing unit configured to determine physiological information at multiple locations of the endocardium surface based on the determined positions of the catheter electrodes and the measured signals at the different catheter positions;
- wherein the processing unit configured to determine the physiological information at the multiple locations of the endocardium surface is configured to determine multiple estimates of the physiological information for each of at least some of the locations on the endocardium based on the measured signals corresponding to at least some of the different catheter positions.
2 more elements
A system comprising:
- a catheter configured to be inserted into a heart cavity having an endocardium surface and to move to each of multiple positions in the heart cavity for which the catheter is spaced from the endocardium surface, the catheter comprising multiple, spatially distributed electrodes, the multiple electrodes configured to measure signals in response to electrical activity in the heart cavity;
- a sensor device configured to determine, for each of the different catheter positions, the positions of the catheter electrodes with respect to the endocardium surface;
- and
- a processing unit configured to determine physiological information at multiple locations of the endocardium surface based on the determined positions of the catheter electrodes and the measured signals at the different catheter positions;
- wherein the sensor device is further configured to determine the position of the catheter with respect to the endocardium surface further configured to register a representation of the endocardium surface, the representation having been obtained prior to inserting the catheter into the heart cavity, with the first coordinate system.
2 more elements
A method comprising:
- inserting a catheter into a heart cavity having an endocardium surface, the catheter comprising multiple, spatially distributed electrodes;
- measuring signals at the catheter electrodes in response to electrical activity in the heart cavity with the catheter spaced from the endocardium surface;
- and
- determining physiological information at multiple locations of the endocardium surface based on the measured signals and positions of the electrodes with respect to the endocardium surface;
- wherein the signals are measured during multiple electrical heart beat cycles and wherein the physiological information is determined, at least in part, by combining information derived from the signals for different heart beat cycles;
- and
- wherein the information derived from the signals for different heart beat cycles comprises a maximum voltage amplitude for each of the different heart beat cycles at different ones of the endocardium surface locations.
4 more elements
A system comprising:
- a catheter configured to be inserted into a heart cavity having an endocardium surface, the catheter comprising multiple, spatially distributed electrodes, the multiple electrodes configured to measure signals in response to electrical activity in the heart cavity with the catheter spaced from the endocardium surface;
- and
- a processing unit configured to determine physiological information at multiple locations of the endocardium surface based on the measured signals and the position of the electrodes with respect to the endocardium surface;
- wherein the signals are measured during multiple electrical heart beat cycles and wherein the processing unit configured to determine physiological information is further configured to, at least in part, combine information derived from the signals for different heart beat cycles;
- wherein the information derived from the signals for different heart beat cycles comprises a maximum voltage amplitude for each of the different heart beat cycles at different ones of the endocardium surface locations.
2 more elements
Dependencies are inferred from the claim text.