Formulation of a mixture of Free-B-ring flavonoids and flavans as a therapeutic agent
AssigneeUnigen Pharmaceuticals, Inc.
InventorQi Jia
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AssigneeUnigen Pharmaceuticals, Inc.
InventorQi Jia
Estimating the term…
The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—Free-B-ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) enzymes, and reducing cox-2 mRNA production. Finally, the present invention includes a method for weight loss and blood glucose control. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier. This invention relates generally to the prevention and treatment of diseases and conditions mediated by the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) pathways, including but not limited to the relief joint discomfort and pain associated with conditions such as osteoarthritis, rheumatoid arthritis, and other injuries that result from overuse.
A method for alleviating joint pain and stiffness and improving mobility, range of motion and flexibility and physical function comprising administering to a host in need thereof an effective amount of a composition comprised of a mixture of an extract derived from Scutellaria enriched for Free-B-ring flavonoids containing baicalin and an extract derived from Acacia enriched for flavans containing catechin or epicatechin, wherein said method alleviates inflammation.
A method for treating pathological conditions related to osteoarthritis and rheumatoid arthritis, said method comprising administering to a host in need thereof an effective amount of a composition comprising a mixture of an extract derived from Scutellaria enriched for Free-B-ring flavonoids containing baicalin and an extract derived from Acacia enriched for flavans containing catechin or epicatechin together with a pharmaceutically acceptable carrier, wherein said method alleviates inflammation.
A method for alleviating joint pain and stiffness and improving mobility, range of motion and flexibility and physical function comprising administering to a host in need thereof an effective amount of a composition comprised of a mixture of an extract derived from Scutellaria enriched for Free-B-ring flavonoids containing baicalin, and an extract derived from Acacia enriched for flavans containing catechin or epicatechin, and one or more of an adjuvant, excipient or carrier;
A method for treating pathological conditions related to osteoarthritis and rheumatoid arthritis comprising administering to a host in need thereof an effective amount of a composition comprised of a mixture of an extract derived from Scutellaria enriched for Free-B-ring flavonoids containing baicalin, and an extract derived from Acacia enriched for flavans containing catechin or epicatechin, and one or more of an adjuvant, excipient or carrier;
A method for alleviating joint pain and stiffness and improving mobility, range of motion and flexibility and physical function comprising administering to a host in need thereof an effective amount of a composition prepared by a method comprising:
A method for treating pathological conditions related to osteoarthritis and rheumatoid arthritis comprising administering to a host in need thereof an effective amount of a composition prepared by a method comprising:
Dependencies are inferred from the claim text.