Methods and apparatuses for the comminution and stabilization of small particles
AssigneeBaxter International Inc.
InventorsJames E. Kipp, Joseph Chung Tak Wong, Monte Wisler, Rhonda Garcia
Life of this patent
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Abstract
Methods and apparatuses for comminuting and stabilizing small particles are provided. In one embodiment, an apparatus moves an organic compound dissolved in a solvent to form a suspension of particles in a first fluid stream and moves the suspension in a second fluid stream, wherein the second fluid stream is oriented and positioned with respect to the first stream to cause shearing between the streams and mixing of at least some of the particles in the first and second streams.
Claims14
A method for preparing a nanoparticle suspension comprising the steps of:
- providing a comminuting apparatus with a chamber;
- dissolving an organic compound in a water miscible first solvent to create a first solution;
- mixing said first solution with a second solvent to precipitate the organic compound to create a suspension of particles outside of said chamber of said comminuting apparatus;
- introducing said suspension into said chamber of said comminuting apparatus;
- moving said suspension through said chamber in a first fluid stream and in a first direction;
- contacting said first fluid stream with an impacting surface;
- and
- redirecting the first fluid stream to flow in a second fluid stream in a second direction that is substantially opposite to said first direction, to cause shearing between the streams and mixing of at least some of the particles from the first and second streams.
A method for modifying a particle suspension comprising the steps of:
- moving a suspension of solid particles from a first entrance point in a first fluid stream;
- moving fluid from a second entrance point in a second fluid stream, said second entrance point being substantially oppositely disposed relative to said first entrance point;
- and
- contacting at least one of said first and second streams with an obstruction disposed between said first and second entrance points to redirect at least one of said first and second streams such that said second fluid stream is oriented to cause shearing between the streams and mixing of at least some of the particles the first and second streams.
Dependencies are inferred from the claim text.