Method of treating hepatitis delta virus infection
AssigneesGeorgetown University, University of Georgia Research Foundation, Inc.
InventorsJohn L. Casey, Brent E. Korba, Paul J. Cote, John L. Gerin, Bud C. Tennant, Chung K. Chu
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Abstract
A method for the treatment for hepatitis delta infection in a host, that includes administering an effective amount of a nucleoside or a nucleoside analog that suppresses the expression of the hepatitis B surface or preS1 antigen in the host 100-fold or more relative to pretreatment values in vivo; or to not more than 1 microgram per milliliter in vivo. In a preferred embodiment, the nucleoside is L-FMAU, or a pharmaceutically acceptable salt or prodrug thereof.
Claims22
A method for the treatment of hepatitis delta infection comprising administering to a host infected with hepatitis delta virus an effective amount of a 2′-fluoro-5-methyl-β-L-arabinofuranosyl-uridine or a pharmaceutically acceptable salt thereof, that reduces the level of hepatitis B surface or preS1 antigen in the host 100-fold or more relative to pretreatment value, wherein the treatment results in the reduction of hepatitis delta virus in the host.
A method for the treatment of hepatitis delta infection comprising:
- administering to a host infected with hepatitis delta virus an effective amount of a 2′-fluoro-5-methyl-β-L-arabinofuranosyl-uridine or a pharmaceutically acceptable salt thereof, that reduces the level of preS1 antigen in the host 100-fold or more relative to pretreatment value, wherein the treatment results in the reduction of hepatitis delta virus in the host.
A method for the treatment of HDV infected host comprising administering of an effective amount of a 2′-fluoro-5-methyl-β-L-arabinofuranosyl-uridine or a pharmaceutically acceptable salt thereof that reduces HBsAg in the infected host to not more than approximately 1 microgram per milliliter, as measured in serum or plasma, wherein the treatment results in the reduction of hepatitis delta virus in the host.
Dependencies are inferred from the claim text.