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US 7,510,868 B2Granted
Chimeric adenoviruses for use in cancer treatment
OwnerPaul Harden, Terry Hermiston +1inventors
InventorsPaul Harden, Terry Hermiston, Irene Kuhn
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Abstract
The present invention relates to oncolytic adenoviruses having therapeutic applications. Recombinant chimeric adenoviruses, and methods to produce them are provided. The chimeric adenoviruses of the invention comprise nucleic acid sequences derived from adenoviral serotypes classified within the subgroups B through F and demonstrate an enhanced therapeutic index.
Claims6
A recombinant chimeric adenovirus, or a variant or derivative thereof, having a genome comprising an E2B region
- wherein said E2B region comprises a nucleic acid sequence derived from a first adenoviral serotype and a nucleic acid sequence derived from a second adenoviral serotype, wherein the nucleotide sequence of the E2B region of said adenovirus comprises SEQ ID NO:3;
- wherein said first and second serotypes are each selected from the adenoviral subgroups B, C, D, E, or F and are distinct from each other;
- and
- wherein said chimeric adenovirus is oncolytic.
1 more element
Dependencies are inferred from the claim text.