Aryl and heteroaryl compounds, compositions and methods of use

A pharmaceutical composition comprising a compound of Formula (I) wherein

• c is equal to 0;
• G is:
• —CO2R1;
• wherein
• R1 is -hydrogen;
• V is:
• —CH2—;
• X is —N(R8)CO—,
• wherein
• R8 is:
• -hydrogen;
• Ar1 is a mono-substituted phenyl group, wherein the substituent is selected from the group consisting of:
• -aryl, -arylene-alkyl, -D-aryl, -D-alkylene-arylene-alkyl, -arylene-D-alkyl, -arylene-D-R10, and -D-alkylene-arylene-aryl,
• wherein
• R10 is -aryl or -alkylene-aryl, and
• D is —O—, or —N(R11)—,
• wherein R11 is:
• -hydrogen, -alkyl, or -aryl;
• Ar2 is a substituted phenyl having 2 to 5 substituents wherein the phenyl is substituted at an ortho and a meta position on Ar2 relative to X;
• and wherein the substituents are independently selected from the group consisting of:
• -fluoro, -chloro, -bromo, iodo, -cyano, -nitro, -perfluoroalkyl, -T1-R14, -alkyl, -aryl, -arylene-alkyl, -T1-alkyl, -T1-alkylene-aryl, -T1-alkylene-arylene-aryl, -T1-alkylene-arylene-alkyl, -arylene-T1-alkyl, -T1-arylene-aryl, -T1-arylene-alkyl, -T1aryl, -T1alkylene-T2-R14, and -T1-arylene-T2-R14;
• wherein
• T1 and T2 are independently selected from the group consisting of —CH2—, —O—, —N(R15—, —CON(R15)—, —N(R15)C(O), —N(R15)SO2, and —C(O)—O—;
• wherein
• R14 and R15 are independently selected from the group consisting of:
• -hydrogen, -alkyl, and -aryl,
• and wherein
• the alkyl, aryl, alkylene, and arylene groups in Ar1, Ar2, and R10, R11, R14, and R15, may be optionally substituted 1 to 4 times with a substituent, wherein the substituents are independently selected from the group consisting of:
• a) -hydrogen;
• b) -fluoro
• c) -chloro;
• d) -bromo
• e) -iodo;
• f) -cyano;
• g) -nitro;
• h) -perfluoroalkyl;
• i) -Q-R18;
• j) -Q-alkyl;
• k) -Q-aryl;
• I) -Q-alkylene-aryl;
• m) -Q-alkylene-NR19R20;
• and
• n) -Q-alkyl-W—R21;
• wherein
• Q and W are independently selected from the group consisting of:
• —CH2—, —O—, —N(R22)—, —C(O)—, —CON(R22)—, —N(R22)C(O)—, —N(R22)CON(R23)—, —N(R22)C(O)O—, —OC(O)N(R22)—, —N(R22)SO2—, —SO2N(R22)—, —C(O)—O—, —O—C(O)—, and —N(R22)SO2N(R23)—, wherein
• R18, R19, R20, R21, R22, and R23, are independently selected from the group consisting of:
• -hydrogen, -alkyl, -aryl, -arylene-alkyl, -alkylene-aryl, and -alkylene-arylene-alkyl,
• or a pharmaceutically acceptable salt thereof.