Inhibition of gastric acid production and/or secretion
OwnerGeorge Tachasinventor
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Abstract
The present invention relates to methods for the treatment or prevention of gastric acid disturbances and for reducing the breakdown of acid sensitive agents in the gastrointestinal tract. The present invention also relates to a method for transfecting parietal cells in vivo. The present invention also relates to synthetic oligonucleotides which may be used in these methods.
Claims13
A method for decreasing production or secretion of gastric acid in a human subject in need thereof, which method comprises administering to the subject an effective amount of an oligonucleotide capable of reducing or inhibiting gastric acid production or secretion in the subject, wherein said oligonucleotide consists of from 12 to 30 nucleobases and is entirely complementary to a region of an RNA transcript encoding an alpha chain of the human gastric proton pump.
Dependencies are inferred from the claim text.