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US 7,501,245 B2Granted
Methods and apparatuses for analyzing polynucleotide sequences
AssigneeHelicos BioSciences Corporation
InventorsStephen Quake, Emil Paskalev Kartalov
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Abstract
Methods for high speed, high throughput analysis of polynucleotide sequences, and apparatuses with which to carry out the methods are provided in the invention.
Claims4
A surface for nucleic acid sequencing, said surface comprising a plurality of chemical layers including a poly(dimethylsiloxane) layer, a poly(ethylene glycol) layer, a polyelectrolyte multilayer comprising a tunable negatively charged final layer, a nucleic acid linkage layer and a nucleic acid layer,
- wherein said poly(ethylene glycol) layer is positioned between said poly(dimethylsiloxane) layer and said polyelectrolyte multilayer, and
- wherein said nucleic acid linkage layer attaches said nucleic acid layer to said polyelectrolyte multilayer.
Dependencies are inferred from the claim text.