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US 7,501,052 B2Granted
Method and apparatus for assay of electrochemical properties
AssigneeAgaMatrix, Inc.
InventorsSridhar G. Iyengar, Ian Harding
Life of this patent
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AssigneeAgaMatrix, Inc.
InventorsSridhar G. Iyengar, Ian Harding
Estimating the term…
The presence of a select analyte in the sample is evaluated in an an electrochemical system using a conduction cell-type apparatus. A potential or current is generated between the two electrodes of the cell sufficient to bring about oxidation or reduction of the analyte or of a mediator in an analyte-detection redox system, thereby forming a chemical potential gradient of the analyte or mediator between the two electrodes After the gradient is established, the applied potential or current is discontinued and an analyte-independent signal is obtained from the relaxation of the chemical potential gradient. The analyte-independent signal is used to correct the analyte-dependent signal obtained during application of the potential or current. This correction allows an improved measurement of analyte concentration because it corrects for device-specific and test specific factors such as transport (mobility) of analyte and/or mediator, effective electrode area, and electrode spacing (and as a result, sample volume), without need for separate calibration values. The analysis can be performed using disposable test strips in a hand held meter, for example for glucose testing.
A method of evaluating a sample for the presence of a select analyte comprising the steps of:
A method for determining the effective separation distance between a first electrode and a second electrode in an electrochemical cell, the method comprising the steps of:
A method for determining an effective transport property between a first electrode and a second electrode in an electrochemical cell, the method comprising the steps of:
An apparatus for determining the presence of an analyte in a sample disposed in an electrochemical cell said electrochemical cell comprising two electrodes between which the sample is placed for analysis, said apparatus comprising:
Dependencies are inferred from the claim text.