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US 7,498,445 B2Granted
Thiazole-based nitric oxide donors capable of releasing two or more nitric oxide molecules and uses thereof
AssigneeRenopharm Ltd.
InventorsPeter Assaf, Elham Gazaleen-Mariee, Michael Naveh
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Abstract
Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
Claims2
An NO-donating compound selected from the group consisting of:
- 4-Methyl-5-(-2-nitrooxy-ethyl)-2-(1-nitrooxy-ethyl)-thiazole (Pet-5);
- 1,4-Bis-[4-Methyl-5-(2-nitrooxy)-ethyl)-thiazol-2-yl]-Butane (Pet-13);
- 1,2-Bis-[4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-ethane (Pet-15);
- Bis-[4-Methyl-5-(2-nitrooxy)-ethyl)-thiazol-2-yl]-methane (Pet-16);
- N,N′-Bis-[4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-hydrazine (Pet-42);
- Bis-[4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-disulfide (Pet-54);
- 4-Methyl-5-(2-nitrooxy-ethyl)-2-(4-nitrooxy-pyrrolidin-2-yl)-thiazole (Pet 93);
- 4-Methyl-5-(2-nitrooxy-ethyl)-2-(nitrooxy-thiophen-2-yl-methyl)-thiazole (Pet-95);
- N-[4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-2-nitrooxy-acetamide (Pet 96);
- Bis-[4-methyl-5-(2-nitrooxy-ethyl)-thiazole-2-yl]-diazene (Pet-102);
- 4,4′-Bis-[4-methyl-5-(2-nitrooxy-ethyl)-thiazole-2-yl]-diphenyl-disulfide (Pet-115);
- and
- 4,4′-Dimethyl-5,5′-bis-(2-nitrooxy-ethyl)-[2,2′]bithiazolyl (Pet-118).
10 more elements
Dependencies are inferred from the claim text.