Back to results
US 7,498,168 B2Granted
Tooth progenitor cell and method for its production
AssigneeOdontis Ltd.
InventorPaul Thomas Sharpe
Life of this patent
Estimating the term…
Abstract
The invention relates to the use of a cultured stem cell to produce a tooth progenitor cell.
Claims5
A method for producing a tooth progenitor cell from a) a cultured human or mouse embryonic stem cell, or b) a human or mouse neural stem cell comprising the steps of:
- a) providing a cultured human or mouse embryonic stem cell or the human or mouse neural stem cell,
- b) contacting the stem cell with an oral epithelial cell,
- c) incubating the contacted stem cell of step b) with the oral epithelial cell for a time sufficient to produce a tooth progenitor cell,
- wherein the tooth progenitor cell co-expresses Barx-1 and Dlx-5, and
- wherein the tooth progenitor cell further expresses a combination of tooth gene expression markers capable of specifically identifying the tooth progenitor cell.
2 more elements
A method for inducing differentiation of a cultured human or mouse embryonic stem cell, or b) a human or mouse neural stem cell, the method comprising the steps of:
- a) providing a cultured human or mouse embryonic stem cell or a human or mouse neural stem cell,
- b) contacting the stem cell with an oral epithelial cell,
- c) incubating the contacted stem cell of step b) with the oral epithelial cell for a time sufficient to induce differentiation of the stem cell,
- wherein the stem cell differentiation comprises the co-expression of Barx-1 and Dlx-5.
1 more element
Dependencies are inferred from the claim text.