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US 7,491,690 B2Granted
Self-assembly and mineralization of peptide-amphiphile nanofibers
AssigneeNorthwestern University
InventorsSamuel I. Stupp, Jeffrey D. Hartgerink, Elia Beniash
Life of this patent
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Abstract
Peptide-amphiphilic compositions capable of self-assembly into useful nanostructures.
Claims13
A peptide amphiphile composition comprising a peptide amphiphile selected from the group consisting of
- CCCCGGGSRGD (SEQ ID NO:
- 2),
- CCCCGGGSRGDS (SEQ ID NO:
- 17),
- CCCCGGGSKGE (SEQ ID NO:
- 11),
- CCCCGGGEIKVAV (SEQ ID NO:
- 16),
- AAAAGGGSRGD (SEQ ID NO:
- 9),
- AAAAGGGSKGE (SEQ ID NO:
- 12), and
- GGGSRGD (SEQ ID NO:
- 7),
- wherein the serine residue in the peptide amphiphile is optionally phosphorylated and wherein a C10-C22 hydrocarbon component is attached to the N-terminus of the peptide component, which directs said composition to form a cylindrical micelle in an aqueous medium.
12 more elements
Dependencies are inferred from the claim text.