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US 7,486,865 B2Granted
Substrates for performing analytical reactions
AssigneePacific Biosciences of California, Inc.
InventorsMathieu Foquet, Paul Peluso, Stephen Turner, Daniel Bernardo Roitman, Geoffrey Otto
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Abstract
Substrates, including zero mode waveguide substrates that have been fabricated to provide additional functional elements and/or components including increased volumes for positioning of active surfaces and/or components for the mitigation of negative electrochemical properties of the underlying substrates.
Claims30
A zero mode waveguide substrate, comprising:
- a transparent substrate layer having at least a first surface;
- a metal cladding layer disposed upon the first surface of the transparent substrate layer;
- an aperture disposed through the cladding layer to the transparent substrate layer, and forming a core region surrounded by the metal cladding layer, wherein the core is dimensioned to prevent electromagnetic radiation of a frequency greater than a cut-off frequency from propagating entirely through the core;
- and
- a sacrificial anode disposed upon the cladding layer.
2 more elements
A zero mode waveguide substrate, comprising:
- a transparent substrate layer
- an opaque cladding layer;
- and
- a core, comprising an aperture disposed though the cladding layer and extending at least partially into the transparent substrate layer.
1 more element
A method of monitoring a reaction, comprising:
- providing a reaction mixture within a core of a zero mode waveguide that comprises a metal cladding layer, wherein the zero mode waveguide includes a sacrificial anode;
- and
- monitoring the reaction mixture within an illumination volume of the core.
Dependencies are inferred from the claim text.