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AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsDeborah A. Buonagurio, Alice F. Georgiu, Robert A. Lerch, Bruce B. Mason, Shridhara C. Murthy, Ruth S. Rappaport, Mohinder S. Sidhu, Stephen A. Udem, Timothy J. Zamb
Estimating the term…
Isolated nucleic acid molecules comprising a gene segment from a rhesus rotavirus (RRV) or from one of three rhesus: human reassortant viruses are disclosed, including isolated nucleic acid molecules having a sequence selected from the group consisting of: SEQ ID NO: 1-14, inclusive, and isolated nucleic acid molecules encoding a protein having a sequence selected from the group consisting of SEQ ID NO: 15-28, inclusive, as well as variants of the isolated nucleic acid molecules.
An isolated nucleic acid molecule having the sequence of SEQ ID NO:3.
An isolated nucleic acid molecule having the sequence of SEQ ID NO:3 with a C replacing a T at nucleotide 2388.
A method for determining the stability of a manufactured reassortant rotavirus composition, comprising the determination of the micro-heterogeneity at nucleotide position 2388 of gene 3 encoding the polypeptide having the sequence of SEQ ID NO:
Dependencies are inferred from the claim text.