Method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis
AssigneeViralytics Limited
InventorDarren R. Shafren
Life of this patent
Estimating the term…
Abstract
There are provided methods for treatment of abnormal cells such as cancer cells in a mammal. The methods involve treating the mammal with virus selected from echoviruses and modified forms and combination thereof, which recognize α2β1 for infectivity of the cells. There are also provided methods for screening viruses for use in a method of the invention as well as pharmaceutical compositions for use in the methods.
Claims27
A method for treating abnormal cells in a mammal comprising administering to the mammal an effective amount of an echovirus, which recognizes integrin α2β1 for infectivity of the cells such that at least one of the cells are killed by the virus, wherein the abnormal cell is a cancer cell expressing α2β1.
A method for inducing an immune response in a mammal against abnormal cells expressing integrin α2β1, the method comprising infecting abnormal cells in the mammal with an echovirus, thereby causing lysis of at least one of the cells and inducing an immune response in the mammal against the abnormal cells, wherein the abnormal cell is a cancer cell expressing α2β1.
Dependencies are inferred from the claim text.