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AssigneesNederlandse Organisatie Voor Toegepast, Natuurwetenschappelijk Onderzoek Tno Leids Universitair Medisch Centrum
InventorsJohan Hendrikus Verheijen, Jan Roeland Occo Hanemaaijer, Michaela Diamant
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A method for determining whether a urine sample has been obtained from a subject suffering from a kidney disorder involving kidney damage. The method is based on determining the level of a proteolytic enzyme in urine from the subject. Sample and optionally comparing this level with a reference value. The proteolytic enzyme preferably is a matrix metalloproteases, in particular MMP-2 or MMP-9. The method is particularly suitable for subjects with a condition or disorder that is associated with an increased risk of kidney disorders, such as diabetes. The method may adavnatageously be applied for early detection of kidney damage, in particular when the subject does not yet show any sign of microalbuminuria. The method may also be applied to a subject undergoing dialysis for determining whether the subject is suffering from remodelling of the peritoneal membrane. Thus, the method is particularly suited for patients undergoing continuous ambulatory peritoneal dialysis.
A method for determining whether a urine sample has been obtained from a subject having a kidney disorder, wherein a test of said urine sample indicated that the subject does not exhibit microalbuminuria, the method comprising the steps of:
A method for determining whether a urine sample has been obtained from a subject having a kidney disorder wherein the subject has diabetes type I or diabetes II, wherein a test of said urine sample indicated that the subject does not exhibit microalbuminuria, the method comprising the steps of:
A method for determining whether a urine sample has been obtained from a subject having a kidney disorder, the method comprising the steps of:
Dependencies are inferred from the claim text.