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US 7,480,042 B1Granted
Luminescence reference standards
AssigneeApplied Biosystems, LLC
InventorsJ. Michael Phillips, Aldrich N. K. Lau, Mark F. Oldham, Kevin S. Bodner, Steven J. Boege, Donald R. Sandell, David H. Tracy
Life of this patent
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Abstract
Systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis.
Claims18
A luminescence reference plate for biological samples, the reference plate comprising:
- a support, wherein the support is configured to provide structural support for the luminescence reference plate;
- light-producing elements, wherein the light producing elements comprise a layer positioned on the support;
- light-blocking elements bounding the light-producing elements, wherein the light-blocking elements comprise a mask;
- at least one of a spectral filter layer, an intensity filter layer, and a protective coating layer positioned between the light producing elements and the mask;
- and
- an insulator coupled to the light-blocking elements, wherein the reference plate with an insulator is adapted for use in a thermal cycler having a heated lid.
3 more elements
A system for calibrating an instrument for thermal cycling of a biological sample, the system comprising:
- a thermal cycling device comprising:
- a light source;
- an optical relay structure;
- a detector;
- a thermal block;
- a heated lid;
- and
- a luminescence reference plate in optical communication with the light source and detector through the optical relay structure, wherein the luminescence reference plate contacts with the heated lid and the thermal block, the luminescence reference plate comprising:
- light-producing elements, wherein the light producing elements comprise a layer positioned on the support;
- light-blocking elements bounding the light-producing elements, wherein the light-blocking elements comprise a mask;
- at least one of a spectral filter layer, an intensity filter layer, and a protective coating layer positioned between the light producing elements and the mask;
- and
- an insulator coupled to the light-blocking elements, wherein the reference plate with an insulator is adapted for use in the thermal cycler with the heated lid.
10 more elements
Dependencies are inferred from the claim text.