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US 7,479,572 B2Granted
Formoterol tartrate process and polymorph
AssigneeSepracor Inc.
InventorsGerald J. Tanoury, Chris H. Senanayaka, Donald W. Kessler
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Abstract
A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.
Claims4
A solvent system for conversion of (R,R)-formoterol L-tartrate polymorph B to (R,R)-formoterol L-tartrate polymorph C comprising (R,R)-formoterol L-tartrate polymorph B, isopropyl alcohol, water, and at least 13% toluene, wherein the solvent is maintained at from 45° C. to 50° C.
Dependencies are inferred from the claim text.