4-(2,4-dichloro-5-methoxyphenyl)amino-6-methoxy-7-{[5-substituted-amino)methyl]-3-furyl}-3-quinolinecarbonitriles as kinase inhibitors

A compound of Formula I

• wherein:
• R1 and R2 may be the same or different and are selected from H, alkyl of 1 to 6 carbon atoms, (CH2)nXR4, (CH2)nNZZ′, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, aryl, or heteroaryl;
• R1 and R2 can be taken together with the nitrogen to which they are attached to form a heterocyclic ring optionally having an additional heteroatom selected from nitrogen, oxygen, and sulfur, wherein the sulfur can be mono or di-oxidized, optionally substituted with at least one —R3 on a carbon or nitrogen, or on nitrogen by a group —(CH2)n XR4, —(CH2)nNZZ′, or on carbon by a group —(CH2)qXR4, —(CH2)qNZZ′, halogen
• Z and Z′ are selected from H, alkyl of 1 to 6 carbon atoms alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon-atoms, aryl, or heteroaryl;
• and
• Z and Z′ can be taken together with the nitrogen to which they are attached to form a heterocyclic ring optionally containing an additional heteroatom selected from nitrogen, oxygen and sulfur;
• R3 is alkyl of 1 to 6 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, oxygen, alkylaryl, alkylheteroaryl, cycloalkyl, aryl or heteroaryl, wherein the aryl or heteroaryl are optionally substituted with one or more alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, halogen, —OH, alkylhydroxy or trifluoromethyl;
• R4 is H, alkyl of 1 to 6 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, aryl or heteroaryl;
• X is O, S, NR4;
• n is 2-5;
• q is 0-5;
• and
• pharmaceutically acceptable salts thereof.