Homogeneous preparations of IL-28A mutants
AssigneeZymoGenetics, Inc.
InventorsLowell J. Brady, Kevin M. Klucher, Chung Chan, Dennis L. Dong, Hong Y. Liu, Paul O. Sheppard, Thomas R. Bukowski
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Abstract
Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
Claims14
An isolated polypeptide comprising amino acid residues 1-175 of SEQ ID NO:19.
A fusion protein comprising a polypeptide that comprises amino acid residues 1-175 of SEQ ID NO:19 and a polyalkyl oxide moiety.
A formulation comprising:
- an isolated polypeptide comprising amino acid residues 1-175 of SEQ ID NO:19;
- and
- a pharmaceutically acceptable vehicle.
Dependencies are inferred from the claim text.