Phosphorous-containing compounds with polymeric chains, and methods of making and using the same
AssigneeGuilford Pharmaceuticals Inc.
InventorsKeith Branham, Mahesh V. Chaubal, James P. English, Donna Hall, Zhong Zhao
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Abstract
The present invention relates to novel phosphorus-containing compounds with polymeric chains, and methods of making and using the same. In part, subject compositions containing phosphorus-containing compounds with polymeric chains and a therapeutic agent, and methods of making and using the same, are described. Certain of the subject compositions exhibit reverse thermal gelation.
Claims20
A composition, comprising a phosphorus-containing compound with a star structure represented by the following formula:
- wherein, independently for each occurrence:
- Q represents —O or —N(R3);
- r represents 0 or 1, and s represents 3 or 2, such that r+s=3;
- R1 represents a polymeric chain;
- R2 represents —H, alkyl, cycloalkyl, —O-alkyl, —O-cycloalkyl, cycloalkenyl, —O-cycloalkenyl, aryl, —O-aryl, heterocycle, —O-heterocycle, polycycle, —O-polycycle, or —N(R4)R5;
- R3 represents —H, alkyl, aryl, cycloalkyl, cycloalkenyl, heterocycle, or polycycle;
- R4 and R5, each independently, represent a hydrogen, an alkyl, an alkenyl, —(CH2)m—R6, or R4 and R5, taken together with the N atom to which they are attached complete a heterocycle having from 4 to about 8 atoms in the ring structure;
- m represents an integer from 0-10;
- and
- R6 represents —H, alkyl, cycloakyl, —O-alkyl, —O-cycloalkyl, cycloalkenyl, —O-cycloalkenyl, aryl, —O-aryl, heterocycle, —O-heterocycle, polycycle or —O-polycycle.
A composition, comprising a phosphorus-containing compound with a star structure represented by the following formula:
- wherein, independently for each occurrence:
- Q represents —O or —N(R3);
- r represents 0 or 1, and s represents 3 or 2, such that r+s=3;
- R2 represents —H, alkyl, cycloalkyl, —O-alkyl, —O-cycloalkyl, cycloalkenyl, —O-cycloalkenyl, aryl, —O-aryl, heterocycle, —O-heterocycle, polycycle, —O-polycycle, or —N(R4)R5;
- R3 represents —H, alkyl, aryl, cycloalkyl, cycloalkenyl, heterocycle, or polycycle;
- R4 and R5, each independently, represent a hydrogen, an alkyl, an alkenyl, —(CH2)m—R6, or R4 and R5, taken together with the N atom to which they are attached complete a heterocycle having from 4 to about 8 atoms in the ring structure;
- m represents an integer from 0-10;
- and
- R6 represents —H, alkyl, cycloakyl, —O-alkyl, —O-cycloalkyl, cycloalkenyl, —O-cycloalkenyl, aryl, —O-aryl, heterocycle, —O-heterocycle, polycycle or —O-polycycle;
- R1 comprises:
- wherein
- * represents the central phosphorus atom of Formula I;
- M1 and M2 are each independently are selected from the group consisting of —CH(CH3)—;
- —CH(CH3)CO2CH(CH3)—;
- —(CH2)d—;
- and —(CH2)d—O—;
- wherein d is from 1 to about 12;
- R7 is represented by —O-alkyl;
- n1 and n2 are equal to 1;
- the t1 and t2 units may be in any order for each occurrence to the unit x;
- and
- x is an integer from 1 to about 20.
Dependencies are inferred from the claim text.