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US 7,479,507 B2Granted
Anti-inflammatory substituted phenols and elastomeric compositions for oral delivery of drugs
OwnerAdam Heller, Charles Haymoreinventors
Life of this patent
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Abstract
3,5-di-substituted-4-hydroxybenzylidene phosphonates and sulfonates useful in treating inflammatory disease, particularly osteoarthritis, and elastomeric particles for oral delivery of drugs are disclosed.
Claims11
A method of treating arthritis in a subject comprising administering to the subject a compound comprising the structure of Formula I:
- where:
- X is a phosphonate or sulfonate ion, or an acid, salt, ester, or amide thereof;
- R is H, an alkyl group, or an alkyl group connected to a carbonyl group;
- R1 and R2 are the same or different, and are groups comprising a ring-bound tertiary carbon atom;
- and
- R3 and R4 are the same or different, and are H, F, or CH3.
3 more elements
A method of treating arthritis in a subject comprising administering to the subject a compound comprising the structure:
- where:
- R is H, an alkyl group, an aryl group, a phenol group connected to a carbonyl group or a lactyl group;
- R1 and R2 are the same or different, and are groups comprising a tertiary carbon atom bound to the ring, tert-butyl, trimiethylsilyl, or trifluoromethyl;
- R3 and R4 are the same or different, and are hydrogen, fluorine, or methyl;
- and
- X is a nitrogen atom or an oxygen atom.
3 more elements
Dependencies are inferred from the claim text.