2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors

A compound of Formula I:

• wherein:
• R3 is —CONR7R8, (where R7 is hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl, sulfoalkyl or phosphonoalkyl and R8 is hydrogen, hydroxy, alkyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, carboxyalkyl, sulfoalkyl, phosphonoalkyl, aminocarboxyalkyl, aminocarbonylcarboxyalkyl, trimethylammonioalkyl, aminocarbonylalkyl, -(alkylene)-(OCH2CH2)n Rb (where n is an integer from 1 to 6 and Rb is hydrogen, alkyl, hydroxy, alkoxy, amino or alkylcarbonylamino), aryl, aralkyl, heteroaryl, heteroaralkyl, hetereocycloalkylalkyl, hetereocycloalkylaminocarbonylalkyl or 3-heterocycloalkyl-2-hydroxypropyl or R7 and R8 together with the nitrogen atom to which they are attached form heterocycloalkylamino), -(alkylene)-CONR9R10 (where R9 is hydrogen, hydroxy, alkyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, carboxyalkyl, sulfoalkyl or phosphonoalkyl and R10 is hydrogen, hydroxy, alkyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, carboxyalkyl, sulfoalkyl, phosphonoalkyl, aminocarboxyalkyl, aminocarbonylcarboxyalkyl, trimethylammonioalkyl, aminocarbonylalkyl, alkylene)-(OCH2CH2)n Rb (where n is an integer from 1 to 6 and Rb is hydrogen, alkyl, hydroxy, alkoxy, amino or alkylcarbonylamino), aryl, aralkyl, heteroaryl, heteroaralkyl, hetereocycloalkylalkyl, hetereocycloalkylaminocarbonylalkyl or 3-heterocycloalkyl-2-hydroxypropyl or R9 and R10 together with the nitrogen atom to which they are attached form heterocycloalkylamino), —CONH SO2R11 (where R11 is alkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, or heterocycloalkylalkyl), or -(alkylene)-CONHSO2R11 (where R11 is alkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl, heterocycloalkyl, or heterocycloalkylalkyl);
• and
• Rz is hydrogen, alkyl, haloalkyl, cycloalkyl, alkylthio, halo, hydroxy, hydroxyalkyl, nitro, cyano, alkoxy, alkoxyalkyl, alkoxyalkyloxy, hydroxyalkyloxy, aminoalkyloxy, carboxyalkyloxy, aminocarbonylalkyloxy, haloalkoxy, carboxy, carboxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, cyanoalkyl, alkylsulfonyl, alkylsulfonylalkyl, arylsulfonyl, heteroarylsulfonyl, carbamimidoyl, hydroxycarbamimidoyl, alkoxycarbamimidoyl, alkylsulfonylamino, alkylsulfonylaminoalkyl, alkoxysulfonylamino, alkoxysulfonylaminoalkyl, heterocycloalkylalkylaminocarbonyl, hydroxyalkoxyalkylaminocarbonyl, heterocycloalkylcarbonyl, heterocycloalkylcarbonylalkyl, heterocycloalkyl, heterocycloalkylalkyl, oxoheterocycloalkyl, oxoheterocycloalkylalkyl, heteroaryl, heteroaralkyl, ureido, alkylureido, dialkylureido, ureidoalkyl, alkylureidoalkyl, dialkylureidoalkyl, thioureido, thioureidoalkyl, —COR12 (where R12 is alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, or aminoalkyl), -(alkylene)-COR12 (where R12 is alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, or aminoalkyl), —CONR14R15 (where R14 is hydrogen or alkyl and R15 is hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl or R14 and R15 together with the nitrogen atom to which they are attached from heterocycloamino), -(alkylene)-CONR16R17 (where R16 is hydrogen, alkyl or hydroxyalkyl and R17 is hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl or R14 and R15 together with the nitrogen atom to which they are attached from heterocycloamino), —NR18R19 (where R18 is hydrogen or alkyl and R19 is hydrogen, alkyl, acyl, aryl, aralkyl, heteroaryl, or heteroaralkyl), -(alkylene)-NR20R21 (where R20 is hydrogen, alkyl, or hydroxyalkyl and R21 is hydrogen, alkyl, acyl, alkoxycarbonyl, hydroxyalkyl, alkoxyalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl), —SO2NR22R23 (where R22 is hydrogen or alkyl and R23 is hydrogen, alkyl, aryl, aralkyl, heteroaryl or heteroaralkyl or R22 and R23 together with the nitrogen atom to which they are attached from heterocycloamino), -(alkylene)-SO2NR24R25 (where R24 is hydrogen or alkyl and R25 is hydrogen, alkyl, aryl, aralkyl, heteroaryl or heteroaralkyl or R24 and R25 together with the nitrogen atom to which they are attached from heterocycloamino), —NR26SO2NR27R28 (where R26 and R27 are independently hydrogen or alkyl, and R28 is hydrogen, alkyl, aryl, aralkyl, heteroaryl or heteroaralkyl or R27 and R28 together with the nitrogen atom to which they are attached from heterocycloamino), -(alkylene)-NR29SO2NR30R31 (where R29 and R30 are independently hydrogen or alkyl, and R31 is hydrogen, alkyl, aryl, aralkyl, heteroaryl or heteroaralkyl or R30 and R31 together with the nitrogen atom to which they are attached from heterocycloamino), —CONH-(alkylene)-NR32R33 where R32 is hydrogen or alkyl and R33 is alkyl), or aralkyl;
• and
• R13 is hydrogen, hydroxy, (C1-10)alkoxy, —C(O)R35 where R35 is alkyl, aryl, haloalkyl, or cyanoalkyl, or —C(O)OR36 where R36 is alkyl, hydroxyalkyl, alkoxyalkyl, alkoxycarbonylalkyl, acyl, aryl, or haloalkyl;
• or a pharmaceutically acceptable salt thereof.