Antidepressant piperidine derivatives of heterocyclefused benzodioxans
AssigneeWyeth
InventorsMichael Byron Webb, Gary Paul Stack, Magda Asselin, Deborah Ann Evrard
Life of this patent
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Abstract
Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
Claims18
A compound of formula I:
- wherein
- R1, R2 and R3 are, independently, hydrogen, hydroxy, halo, cyano, carboxamido, carboalkoxy of two to six carbon atoms, trifluoromethyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyl of 2 to 6 carbon atoms, alkanoyloxy of 2 to 6 carbon atoms, amino, mono- or di-alkylamino in which each alkyl group has 1 to 6 carbon atoms, alkanamido of 2 to 6 carbon atoms, alkanesulfonyl of 1 to 6 carbon atoms or alkanesulfonamido of 1 to 6 carbon atoms;
- X and Y, taken together, form —NH—C(R8)═CH—;
- R8 is hydrogen, halo, trifluoromethyl, pentafluoroethyl, or alkyl of 1 to 6 carbon atoms;
- the dotted line represents an optional double bond;
- Z is oxygen or sulfur;
- Q is carbon or nitrogen;
- and
- n is 0 or 1;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.