Substituted spiro azabicyclics as modulators of chemokine receptor activity

A compound of formula (Ia):

• or stereoisomers of pharmaceutically accceptable salts thereof, wherein:
• Z is O;
• R1 and R2 are H;
• R3 is phenyl, naphthyl, pyridinyl, thiophenyl, furanyl, indazolyl, benzothiazolyl, benzimidazolyl, benzothiophenyl, benzofuranyl, benzoxazolyl, benzisoxazolyl, quinolinyl, isoquinolinyl, imidazolyl, indolyl, indolinyl, indazolyl, isoindolyl, isothiadiazolyl, isoxazolyl, piperidinyl, pyrazolyl, 1,2,4-triazolyl, 1,2,3-triazolyl, tetrazolyl, thiadiazolyl, thiazolyl, oxazolyl, pyrazinyl or pyrimidinyl, wherein the phenyl and naphthyl are substituted with 0-5 R15 and the pyridinyl, thiophenyl, furanyl, indazolyl, benzothiazolyl, benzimidazolyl, benzothiophenyl, benzofuranyl, benzoxazolyl, benzisoxazolyl, quinolinyl, isoquinolinyl, imidazolyl, indolyl, indolinyl, indazolyl, isoindolyl, isothiadiazolyl, isoxazolyl, piperidinyl, pyrazolyl, 1,2,4-triazolyl, 1,2,3-triazolyl, tetrazolyl, thiadiazolyl, thiazolyl, oxazolyl, pyrazinyl and pyrimidinyl are substituted with 0-3 R15;
• R4 is absent, taken with the nitrogen to which it is attached to form an N-oxide, or selected from C1-8 alkyl, (CH2)rC3-6 cycloalkyl, and a (CH2)r—C3-10 carbocycle substituted with 0-3 R4c;
• R4c, at each occurrence, is independently selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, (CH2)rSC1-5 alkyl, (CH2)rNR4aR4a, and (CH2)rphenyl;
• R5 is selected from
• Y is selected from O, N(R25), S, S(O), and S(O)2;
• ring B is a 5-7 membered cycloalkyl ring with containing a C═O, and being substituted with 0-2 R11a, wherein the cycloalkyl ring is fused with a benzo group substituted with 0-3 R16 or is fused with a 5-6 membered aromatic heterocyclic ring with 0-3 N, 0-1 O, or 0-1 S, the heterocyclic ring being substituted with 0-3 R16;
• alternatively, ring B is a 5-7 membered saturated heterocyclic ring with 0-1 O, N(R25), S, S(O), and S(O)2, substituted with 0-2 R11a, wherein the heterocyclic ring is fused with a benzo group substituted with 0-3 R16 or is fused with a 5-6 membered aromatic heterocyclic ring with 0-3 N, 0-1 O, or 0-1 S, the heterocyclic ring being substituted with 0-3 R16;
• provided that if ring B is a heterocyclic ring, then the number of carbon atoms separating the heteroatom of ring B and the nitrogen atom of formula (Ia) bonded to R5 is at least 2;
• R5′ is selected from H, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, (CH2)qC(O)R4b, (CH2)qC(O)NR4aR4a, (CH2)qC(O)OR4b, and a (CH2)r—C3-10 carbocycle substituted with 0-3 R4c;
• alternatively, in formula (Ib), R5 and R5′ may together form a saturated ring containing 5 to 7 atoms optionally substituted with C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, (CH2)qC(O)R4b, (CH2)qC(O)NR4aR4a, (CH2)qC(O)OR4b, (CH2)r—R5a, or O—R5a;
• R5a is phenyl substituted with 1-3 R16;
• R6, at each occurrence, is independently selected from C1-4 alkyl, (CH2)rC3-6 cycloalkyl, (CH2)qNR6aR6a, (CH2)qOH, (CH2)qOR6b, (CH2)rC(O)OH, (CH2)rC(O)R6b, (CH2)rC(O)NR6aR6a, (CH2)qNR6dC(O)R6a, (CH2)rS(O)2NR6aR6a, (CH2)rNR6dS(O)2R6b, and (CH2)tphenyl substituted with 0-3 R6c;
• R6a, at each occurrence, is independently selected from H, methyl, ethyl, propyl, i-propyl, butyl, cyclopropyl, cyclopentyl, cyclohexyl, and phenyl;
• R6b, at each occurrence, is independently selected from methyl, ethyl, propyl, i-propyl, butyl, cyclopropyl, cyclopentyl, cyclohexyl, and phenyl;
• R6c, at each occurrence, is independently selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, (CH2)rSC1-5 alkyl, and (CH2)rNR6dR6d;
• R16d, at each occurrence, is independently selected from methyl, ethyl, propyl, i-propyl, butyl, cyclopropyl, cyclopentyl, and cyclohexyl.
• R11a and R12a, at each occurrence, are independently selected from H, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)tC3-6 cycloalkyl, (CF2)tCF3, (CH2)rN(R18a)R18b, (CH2)rOH, (CH2)rOR19, (CH2)rSH, (CH2)rSR19, (CH2)rC(O)OH, (CH2)rC(O)R19, (CH2)rC(O)N(R18a)R18b, (CH2)rN(R18c)C(O)R19, (CH2)rC(O)OR19, (CH2)rOC(O)R19, (CH2)rS(O)R19, (CH2)rS(O)2R19, (CH2)rS(O)2N(R18a)R18b, (CH2)rN(R18c)S(O)2R19, and (CH2)tphenyl substituted with 0-3 R18;
• with the proviso that if s is 1, then r contained within the definition of such R11a and R12a attached to carbon atoms bonded directly to Y must be greater than 0;
• R11b, R12b, R14a and R14b, at each occurrence, are independently selected from H, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, (CF2)rCF3, (CH2)qN(R18aYR18b, (CH2)qOH, (CH2)qOR19, (CH2)qSH, (CH2)qSR19, (CH2)rC(O)OH, (CH2)rC(O)R19, (CH2)rC(O)N(R18a)R18b, (CH2)qN(R18c)C(O)R19, (CH2)rC(O)OR19, (CH2)qOC(O)R19, (CH2)qS(O)R19, (CH2)qS(O)2R19, (CH2)qS(O)2N(R18a)R18b, CH2)qN(R18c)S(O)2R19, and (CH2)rphenyl substituted with 0-3 R18;
• R15, at each occurrence, is independently selected from C1-8 alkyl, (CH2)rC3-6 cycloalkyl, Cl, Br, I, F, NO2, CN, (CHR′)rNR15aR15a, (CHR′)rOH, (CHR′)rO(CHR′)rR15d, (CHR′)rSH, (CHR′)rC(O)H, (CHR′)rS(CHR′)rR15d, (CHR′)rC(O)OH, (CHR′)rC(O)(CHR′)rR15b, (CHR′)rC(O)NR15aR15a, (CHR′)rNR15fC(O) (CHR′)rR15b, (CHR′)rNR15fC(O)NR15fR15f, (CHR′)rC(O)O(CHR′)rR15d, (CHR′)rOC(O)(CHR′)rR15b, (CHR′)rC(═NR15f)NR15aR15a, (CHR′)rNHC(═NR15f)NR15fR15f, (CHR′)rS(O)(CHR′)rR15b, (CHR′)rS(O)2(CHR′)rR15b, (CHR′)rS(O)2NR15aR15a, (CHR′)rNR15fS(O)2(CHR′)rR15b, C1-6 haloalkyl, C2-8 alkenyl substituted with 0-3 R′, C2-8 alkynyl substituted with 0-3 R′, (CHR′)rphenyl substituted with 0-3 R15e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R15e;
• R′, at each occurrence, is independently selected from H, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, and (CH2)rphenyl substituted with R15e;
• R15a, at each occurrence, is independently selected from H, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, a (CH2)r—C3-10 carbocycle substituted with 0-5 R15e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R15e;
• R15b, at each occurrence, is independently selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, a (CH2)r—C3-6 carbocycle substituted with 0-3 R15e, and (CH2)r-5-6 membered heterocyclic system with 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R15e;
• R15d, at each occurrence, is independently selected from C2-8 alkenyl, C2-8 alkynyl, C1-6 alkyl substituted with 0-3 R15e, a (CH2)r—C3-10 carbocycle substituted with 0-3 R15e, and a (CH2)r5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R15e;
• R15e, at each occurrence, is independently selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, OH, SH, (CH2)rSC1-5 alkyl, (CH2)rNR15fR15f, and (CH2)rphenyl;
• R15f, at each occurrence, is independently selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl;
• R16, at each occurrence, is independently selected from C1-8 alkyl, (CH2)rC3-6 cycloalkyl, CF3, Cl, Br, I, F, NR16aR16a, NO2, CN, OH, OR16d, C(O)R16b, C(O)NR16aR16a, and NR16fC(O)R16b;
• R6a, at each occurrence, is independently selected from H, methyl, ethyl, propyl, i-propyl, butyl, cyclopropyl, cyclopentyl, cyclohexyl, and (CH2)rphenyl substituted with 0-3 R16e;
• R16b, at each occurrence, is independently selected from methyl, ethyl, propyl, i-propyl, butyl, cyclopropyl, cyclopentyl, cyclohexyl, and (CH2)rphenyl substituted with 0-3 R16e;
• R16d, at each occurrence, is independently selected from methyl, ethyl, propyl, i-propyl, butyl, and phenyl;
• R16e, at each occurrence, is independently selected from methyl, ethyl, propyl, i-propyl, butyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, OH, and (CH2)rOC1-5 alkyl;
• R16f, at each occurrence, is independently selected from H, methyl, ethyl, propyl, i-propyl, and butyl
• R18, at each occurrence, is independently selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, (CH2)rSC1-5 alkyl, (CH2)rS(O)C1-5 alkyl, (CH2)rS(O)2C1-5 alkyl, (CH2)rS(O)2N(R18a)R18b, (CH2)rN(R18c)C(O)C1-5 alkyl (CH2)rN(R18c)S(O)2C1-5 alkyl, (CH2)rC(O)N(R18a)R18b, (CH2)rC(O)OC1-5 alkyl, (CH2)rC(O)C1-5 alkyl, and (CH2)rN(R18a)R18b;
• R18a, R18b, and R18c, at each occurrence, are independently selected from H, C1-6 alkyl, and C3-6 cycloalkyl;
• alternatively, R18a and R18b along with the nitrogen to which both are attached form a pyrrolidine, piperidine, piperazine or morpholine ring;
• R19, at each occurrence, is independently selected from C1-6 alkyl, C3-6 cycloalkyl, and phenyl substituted with 0-3 R18;
• R25, at each occurrence, is independently selected from H, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, (CH2)rC(O)R19, (CH2)rC(O)N(R18a)R18b, (CH2)rC(O)OR19, (CH2)rS(O)2R19, (CH2)rS(O)2N(R18a)R18b, and (CH2)rphenyl substituted with 0-3 R18;
• a is selected from 0 and 1;
• b is selected from 0, 1, and 2;
• with the proviso that a+b is 2;
• c is selected from 0 1, and 2;
• d is selected from 1, 2 and 3;
• with the proviso that c+d is 2, 3 and 4;
• m is selected from 0, 1, and 2;
• s is selected from 0 and 1;
• with the proviso:
• m+s is selected from 0, 1, and 2;
• v is selected from 0, 1, 2, and 3;
• with the proviso:
• that the number of atoms in the shortest path linking the nitrogen to which R5 is attached and the fused benzo or aromatic heterocyclic ring of B contained within such R5 is less than or equal to 4;
• r is selected from 0, 1, 2, 3, 4, and 5;
• t is selected from 0, 1, 2, 3, 4, and 5;
• q is selected from 1, 2, 3, 4, and 5;
• and
• u is selected from 0, 1 and, 2.
• provided that provided that said compound is not a compound wherein:
• R3 is mono, di or trisubstituted phenyl or naphthyl, wherein the substituents are hydroxy, C1-3 alkyl, cyano, Cl, Br, I, F or trifluoromethyl;
• R6 is NR6aR6a or OH R6a is H, C1-6 alkyl, or phenyl substituted with 0-3 R6c;
• R6c is C1-3 alkyl, Cl F Br I CN, CF3, or OH;
• and R4 is absent taken with the nitrogen to which it is attached to form an N-oxide, C1-4 alkyl, or phenylC1-4 alkyl.

A compound of Table 1, wherein Table 1is as follows:

• TABLE 1
• Mass
• Exam-
• spec,
• ple
• c
• d
• R3
• R5
• (M + H)+
• 1
• 1
• 3
• 3-(1-methyl-tetrazol-
• 4-F—C6H4—(CH2)2—
• 492
• 5-yl)-C6H4
• 2
• 1
• 3
• 3-(1-methyl-tetrazol-
• 4-F—C6H4—CH2—
• 478
• 5-yl)-C6H4
• 3
• 2
• 2
• 3-(1-methyl-tetrazol-
• 4-F—C6H4—(CH2)3—
• 506
• 5-yl)-C6H4
• 4
• 2
• 2
• 3-(1-methyl-tetrazol-
• 4-F—C6H4—(CH2)2—
• 492
• 5-yl)-C6H4
• 5
• 2
• 2
• 3-(1-methyl-tetrazol-
• 4-Cl—C6H4—(CH2)2—
• 508
• 5-yl)-C6H4
• 6
• 2
• 2
• 3-(1-methyl-tetrazol-
• C6H4—(CH2)3—
• 488
• 5-yl)-C6H4
• 7
• 2
• 2
• 3-(1-methyl-tetrazol-
• 2,4-Cl2—C6H4—(CH2)2—
• 542
• 5-yl)-C6H4
• 8
• 2
• 2
• 3-(1-methyl-tetrazol-
• C6H4—CH═CHCH2—
• 486
• 5-yl)-C6H4
• 9
• 2
• 2
• 3-(1-methyl-tetrazol-
• 4-Cl—C6H4—(CH2)3—
• 522
• 5-yl)-C6H4
• 10
• 1
• 3
• 4-methyl-5-
• 4-F—C6H4—(CH2)2—
• 473
• acetylthiazol-2-yl
• 11
• 1
• 3
• 3-ethyl-5-(1-methyl-
• 4-F—C6H4—(CH2)2—
• 520
• tetrazol-5-yl)-C6H4
• 12
• 1
• 3
• 3-ethyl-5-(1-methyl-
• 4-F—C6H4—CH2—
• 506
• tetrazol-5-yl)-C6H4
• 13
• 1
• 3
• 4-methyl-5-
• 4-F—C6H4—CH2—
• 459
• acetylthiazol-2-yl

A compound of formula (Ia):

• or stereoisomers of pharmaceutically accceptable salts thereof, wherein:
• Z is O;
• R1 and R2 are H;
• C1-8 alkyl, C2-8 alkenyl, and C2-8 alkyl;
• R3 is selected from a (CR3′R3′)r—C3-10 carbocycle substituted with 0-5 R15 and a (CR3′R3′)r-5-10 membered heterocyclic system with 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R15;
• R3′, at each occurrence, is independently selected from H, C1-6 alkyl, (CH2)rC3-6 cycloalkyl, and phenyl;
• R4 is absent,
• R5 is
• R5a is selected from a C3-10 carbocycle substituted with 0-5 R16, and a 5-10 membered heterocyclic system with 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R16;
• R6, at each occurrence, is independently selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)tC3-6 cycloalkyl, (CF2)rCF3, CN, (CH2)rNR6aR6a, (CH2)rOH, (CH2)rOR6b, (CH2)rSH, (CH2)rSR6b, (CH2)rC(O)OH, (CH2)rC(O)R6b, (CH2)rC(O)NR6aR6a, (CH2)rNR6dC(O)R6a, (CH2)rC(O)OR6b, (CH2)rOC(O)R6b, (CH2)rS(O)R6b, (CH2)rS(O)2R6b, (CH2)rS(O)2NR6aR6a, (CH2)rNR6dS(O)2R6b, and (CH2)tphenyl substituted with 0-3 R6c;
• with the proviso that if R6 is attached to a carbon atom which also is attached to a nitrogen atom, or if two occurrences of R6 are attached to the same carbon atom, then r contained within the definition of such R6 must be greater than 0;
• R6a, at each occurrence, is independently selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl substituted with 0-3 R6c;
• R6b, at each occurrence, is independently selected from C1-6 alkyl, C3-6 cycloalkyl, and phenyl substituted with 0-3 R6c;
• R6c, at each occurrence, is independently selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, (CH2)rSC1-5 alkyl, and (CH2)rNR6dR6d;
• R6d, at each occurrence, is independently selected from H, C1-6 alkyl, and C3-6 cycloalkyl;
• R11a and R12a, at each occurrence, are independently selected from H, methyl, ethyl and OH;
• R11b, R12b, R14a, and R14b, at each occurrence, are independently selected from H, methyl and ethyl;
• R15, at each occurrence, is independently selected from C1-8 alkyl, (CH2)rC3-6 cycloalkyl, Cl, Br, I, F, NO2, CN, (CHR′)rNR15aR15a, (CHR′)rOH, (CHR′)rO(CHR′)rR15d, (CHR′)rSH, (CHR′)rC(O)H, (CHR′)rS(CHR′)rR15d, (CHR′)rC(O)OH, (CHR′)rC(O)(CHR′)rR15b, (CHR′)rC(O)NR15aR15a, (CHR′)rNR15fC(O) (CHR′)rR15b, (CHR′)rNR15fC(O)NR15fR15f, (CHR′)rC(O)O(CHR′)rR15d, (CHR′)rOC(O)(CHR′)rR15b, (CHR′)rC(═NR15f)NR15aR15a, (CHR′)rNHC(═NR15f)NR15fR15f, (CHR′)rS(O)(CHR′)rR15b, (CHR′)rS(O)2(CHR′)rR15b, (CHR′)rS(O)2NR15aR15a, (CHR′)rNR15fS(O)2(CHR′)rR15b, C1-6 haloalkyl, C2-8 alkenyl substituted with 0-3 R′, C2-8 alkynyl substituted with 0-3 R′, (CHR′)rphenyl substituted with 0-3 R15e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R15e;
• R′, at each occurrence, is independently selected from H, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, and (CH2)rphenyl substituted with R15e;
• R15a, at each occurrence, is independently selected from H, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, a (CH2)r—C3-10 carbocycle substituted with 0-5 R15e, and a (CH2)r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R15e;
• R15b, at each occurrence, is independently selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, a (CH2)r—C3-6 carbocycle substituted with 0-3 R15e, and (CH2)r-5-6 membered heterocyclic system with 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R15e;
• R15d, at each occurrence, is independently selected from C2-8 alkenyl, C2-8 alkynyl, C1-6 alkyl substituted with 0-3 R15e, a (CH2)r—C3-10 carbocycle substituted with 0-3 R15e, and a (CH2)r5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R15e;
• R15e, at each occurrence, is independently selected from C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, (CH2)rC3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, OH, SH, (CH2)rSC1-5 alkyl, (CH2)rNR15fR15f, and (CH2)rphenyl;
• R15f, at each occurrence, is independently selected from H, C1-6 alkyl, C3-6 cycloalkyl, and phenyl;
• R16, at each occurrence, is independently selected from Cl, F, CF3, and CN;
• R18, at each occurrence, is independently selected from C1-6 alkyl, C3-6 cycloalkyl, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOC1-5 alkyl, (CH2)rOH, (CH2)rSC1-5 alkyl, (CH2)rS(O)C1-5 alkyl, (CH2)rS(O)2C1-5 alkyl, (CH2)rS(O)2N(R18a)R18b, (CH2)rN(R18c)C(O)C1-5 alkyl (CH2)rN(R18c)S(O)2C1-5 alkyl, (CH2)rC(O)N(R18a)R18b, (CH2)rC(O)OC1-5 alkyl, (CH2)rC(O)C1-5 alkyl, and (CH2)rN(R18a)R18b;
• R18a, R18b, and R18c, at each occurrence, are independently selected from H, C1-6 alkyl, and C3-6 cycloalkyl;
• alternatively, R18a and R18b along with the nitrogen to which both are attached form a pyrrolidine, piperidine, piperazine or morpholine ring;
• R19, at each occurrence, is independently selected from C1-6 alkyl, C3-6 cycloalkyl, and phenyl substituted with 0-3 R18;
• R25, at each occurrence, is independently selected from H, methyl, ethyl, propyl, i-propyl, butyl, cyclopropyl,cyclopentyl, cyclohexyl, (CH2)rC(O)R19, (CH2)rC(O)N(R18a)R18b, (CH2)rC(O)OR19, and (CH2)rphenyl substituted with 0-3 R18.
• a is selected from 0 and 1;
• b is selected from 0, 1, and 2;
• with the proviso that a+b is 2;
• c is selected from 0 1, and 2;
• d is selected from 1, 2 and 3;
• with the proviso that c+d is 2, 3 and 4;
• m is selected from 0, 1, and 2;
• r is selected from 0 , 1, 2, 3, 4, and 5;
• q is selected from 1, 2, 3, 4, and 5;
• and
• u is selected from 0, 1 and, 2;
• provided that said compound is not a compound wherein;
• R1 and R2 are H or C1-6 alkyl;
• R3 is a mono or disubstituted C1-6 alkyl, wherein the substituent is phenyl;
• phenyl or naphthyl or mono, di or trisubstituted phenyl or naphthyl, wherein the substituents are hydroxy, C1-3 alkyl, cyano, Cl, Br, I, F or trifluoromethyl;
• R6 is NR6aR6a or OH;
• R6a is H, C1-6 alkyl, or phenyl substituted with 0-3 R6c;
• R6c is C1-3 alkyl, Cl, F, Br, I, CN, CF3, or OH.