3-monosubstituted tropane derivatives as nociceptin receptor ligands

A compound represented by the formula

• or a pharmaceutically acceptable salt thereof, wherein
• R1 is R4-aryl-, R4-arylalkyl-, R4-heteroaryl-, R4-heteroarylalkyl-, R4-cycloalkyl-, R4-cycloalkylalkyl-, R4-heterocycloalkyl-, R4-heterocycloalkylalkyl-;
• R2 is R5-aryl-, R5-arylalkyl-, R5-heteroaryl-, R5-heteroarylalkyl-, R5-cycloalkyl-, R5-cycloalkylalkyl-, R5-heterocycloalkyl-, R5-heterocycloalkylalkyl-;
• R3 is R6-alkyl-, R6-aryl-, R6-heteroaryl-, R6-cycloalkyl-, R6-heterocycloalkyl-;
• X is a bond, (C1-C3)alkylene, —(CH2)m—N(R7)—(CH2)n—, —(CH2)m—O—(CH2)n—, —(CH2)m—S—(CH2)n—, —C(O)—, —CH(OH)—, —C(O)N(R7)—, —C(O)N(R7)-alkylene or —N(R7)C(O)—;
• n is 0, 1, 2, 3;
• 4, 5 or 6;
• m is 0, 1, 2, 3;
• 4, 5 or 6;
• provided that the sum of m and n is 0, 1, 2, 3;
• 4, 5 or 6;
• each R4 and R5 is 1 to 3 substituents independently selected from the group consisting of H, halo, alkyl, cycloalkyl, —CN, —CF3, —(CH2)p—OR8, —N(R10)2 and —(CH2)n—N(R10)2;
• R6 is 1 to 3 substituents independently selected from the group consisting of H, halo, alkyl, cycloalkyl, heterocycloalkyl, heterocycloalkylalkyl, —CN, cyanoalkyl, —CF3, —C(O)alkyl, —(CH2)p—OR8, —COOR8, —N(R10)2, —(CH2)n—N(R10)2 and —C(O)N(R10)2;
• p is 0, 1, 2, 3;
• 4, 5 or 6;
• R7 is H or alkyl;
• R8 and R9 are independently selected from the group consisting of H, alkyl, cycloalkyl, haloalkyl, hydroxyalkyl, alkoxy, alkoxyalkyl, aminoalkyl, alkyl-C(O)— and alkyl-C(O)—N(R7)—C(O)—;
• and
• R10 is independently selected from the group consisting of H and alkyl.