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US 7,479,491 B2Granted
Azanthranylalkyl and -cycloalkyl amides and their use as VEGF receptor inhibitors
AssigneeNovartis AG
InventorsDieter Seidelmann, Martin Krueger, Eckhard Ottow, Andreas Huth, Karl-Heinz Thierauch, Andreas Menrad, Martin Haberey
Life of this patent
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Abstract
The invention relates to substituted anthranylalkyl and -cycloalkyl amides of general formula (I) and to their use as medicaments for treating diseases caused by persistent angiogenesis.
Claims3
A compound of the formula
- in which
- A is the group —NR7;
- W is oxygen or sulfur,
- Z is a bond,
- R1 is branched or unbranched C1-12alkyl or C2-12alkenyl which is optionally substituted once or many times by halogen, hydroxy, C1-6alkyloxy, aralkyloxy, C1-6alkyl and/or NR11R12;
- X is C1-6alkyl;
- R2 signifies pyridyl;
- R3, R4, R5 and R6 are hydrogen, halogen;
- or C1-6alkoxy, C1-6alkyl, C1-6carboxyalkyl either unsubstituted or optionally substituted once or many times by halogen;
- R7 is hydrogen, C1-6alkyl or C1-8cycloalkyl;
- R8, R9 and R10 are hydrogen or C1-6alkyl;
- and
- R11 and R12 are hydrogen or C1-6alkyl or form a ring which may contain a further hetero atom and may be optionally substituted by C1-6alkyl,
- except those compounds,
- in which
- W is oxygen;
- Z is a bond;
- X is C2alkyl;
- R2 signifies unsubstituted 4-pyridyl;
- R3, R4, R6, R7 and R9 are, respectively, hydrogen;
- R5 is hydrogen or chlorine;
- and
- R1 signifies n-propyl, cyclopropyl or allyl,
- and the salts thereof.
21 more elements
Dependencies are inferred from the claim text.